{"id":97,"date":"2023-09-18T15:25:58","date_gmt":"2023-09-18T07:25:58","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=97"},"modified":"2023-09-18T16:01:43","modified_gmt":"2023-09-18T08:01:43","slug":"%e9%98%bf%e6%9d%a5%e6%9b%bf%e5%b0%bc-%e8%89%be%e4%b9%90%e6%9b%bf%e5%b0%bc-%e9%98%bf%e9%9b%b7%e6%9b%bf%e5%b0%bc-%e8%80%81%e6%8c%9d%e4%b8%9c%e7%9b%9f%e5%88%b6%e8%8d%af-alynni","status":"publish","type":"post","link":"https:\/\/yaozhiyou.com\/?p=97","title":{"rendered":"\u963f\u6765\u66ff\u5c3c\/\u827e\u4e50\u66ff\u5c3c\/\u963f\u96f7\u66ff\u5c3c\/\u8001\u631d\u4e1c\u76df\u5236\u836f-Alynni"},"content":{"rendered":"\n<figure class=\"wp-block-image size-medium\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"http:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/09\/100pei.com_2019-10-08_12-45-58-300x300.jpg\" alt=\"\" class=\"wp-image-98\" srcset=\"https:\/\/yaozhiyou.com\/wp-content\/uploads\/2023\/09\/100pei.com_2019-10-08_12-45-58-300x300.jpg 300w, https:\/\/yaozhiyou.com\/wp-content\/uploads\/2023\/09\/100pei.com_2019-10-08_12-45-58-150x150.jpg 150w, https:\/\/yaozhiyou.com\/wp-content\/uploads\/2023\/09\/100pei.com_2019-10-08_12-45-58.jpg 560w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\">\u9002\u5e94\u75c7\uff1a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/h3>\n\n\n\n<p>\u6307\u793a\u901a\u8fc7FDA\u6279\u51c6\u7684\u6d4b\u8bd5\u68c0\u6d4b\u5230\u7684\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9633\u6027\uff0c\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6bcf\u5929\u53e3\u670d2\u6b21(\u6bcf\u65e5\u603b\u5242\u91cf1200 mg)\uff0c\u6bcf\u6b21600 mg(4\u7c92150 mg\u80f6\u56ca) \uff0c\u6bcf\u65e5\u4e24\u6b21\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u4e0d\u53ef\u63a5\u53d7\u7684\u6bd2\u6027\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5242\u578b\uff1a150mg\u80f6\u56ca<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">\u5242\u91cf\u8c03\u6574<\/h3>\n\n\n\n<p>\u5242\u91cf\u51cf\u5c11\u8ba1\u5212<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8d77\u59cb\u5242\u91cf\uff1a600mg \u6bcf\u6b21\uff0c\u4e00\u5929\u4e24\u6b21<\/li>\n\n\n\n<li>\u9996\u6b21\u5242\u91cf\u51cf\u5c11\uff1a450\u6beb\u514b \u6bcf\u6b21\uff0c\u4e00\u5929\u4e24\u6b21<\/li>\n\n\n\n<li>\u7b2c\u4e8c\u5242\u91cf\u51cf\u5c11\uff1a300\u6beb\u514b \u6bcf\u6b21\uff0c\u4e00\u5929\u4e24\u6b21<\/li>\n\n\n\n<li>\u5982\u679c\u60a3\u8005\u4e0d\u80fd\u8010\u53d7300 mg&nbsp; \u6bcf\u6b21\uff0c\u5219\u505c\u6b62\u4f7f\u7528<\/li>\n<\/ul>\n\n\n\n<p>\u80be\u6bd2\u6027<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>3\u7ea7\uff1a\u6682\u65f6\u505c\u6b62\u76f4\u81f3\u8840\u6e05\u808c\u9150\u6062\u590d\u81f3\u22641.5xULN\uff0c\u7136\u540e\u4ee5\u51cf\u5c11\u7684\u5242\u91cf\u6062\u590d<\/li>\n\n\n\n<li>4\u5e74\u7ea7\uff1a\u6c38\u4e45\u505c\u6b62<\/li>\n<\/ul>\n\n\n\n<p>\u809d\u6bd2\u6027<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ALT\u6216AST\u5347\u9ad8&gt; 5x ULN\uff0c\u603b\u80c6\u7ea2\u7d20\uff08TB\uff09\u22642xULN\uff1a\u6682\u65f6\u505c\u7528\u81f3\u6062\u590d\u81f3\u57fa\u7ebf\u6216\u22643\u500dULN\uff0c\u7136\u540e\u4ee5\u51cf\u91cf\u5242\u91cf\u6062\u590d<\/li>\n\n\n\n<li>ALT\u6216AST\u5347\u9ad8&gt; 3x ULN\uff0c\u7ed3\u80a0\u5347\u9ad8&gt; 2x ULN\uff0c\u65e0\u80c6\u6c41\u6de4\u79ef\u6216\u6eb6\u8840\uff1a\u6c38\u4e45\u505c\u836f<\/li>\n\n\n\n<li>TB\u5347\u9ad8&gt; 3x ULN\uff1a\u6682\u65f6\u505c\u6b62\u76f4\u81f3\u6062\u590d\u5230\u57fa\u7ebf\u6216\u22641.5xULN\uff0c\u7136\u540e\u4ee5\u51cf\u5c11\u7684\u5242\u91cf\u6062\u590d<\/li>\n<\/ul>\n\n\n\n<p>\u95f4\u8d28\u6027\u80ba\u75c5\uff08ILD\uff09\/\u80ba\u708e<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4efb\u4f55\u4e0e\u6cbb\u7597\u76f8\u5173\u7684ILD \/\u80ba\u708e\u7b49\u7ea7\uff1a\u6c38\u4e45\u505c\u836f<\/li>\n<\/ul>\n\n\n\n<p>\u5fc3\u52a8\u8fc7\u7f13<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u75c7\u72b6\u6027\u5fc3\u52a8\u8fc7\u7f13\n<ul class=\"wp-block-list\">\n<li>\u4fdd\u7559\u76f4\u81f3\u6062\u590d\u65e0\u75c7\u72b6\u6027\u5fc3\u52a8\u8fc7\u7f13\u6216\u5fc3\u7387\u226560\u6b21\/\u5206<\/li>\n\n\n\n<li>\u5982\u679c\u786e\u5b9a\u5e76\u505c\u6b62\u4f9b\u5e94\u4f34\u968f\u836f\u7269\uff0c\u6216\u8005\u8c03\u6574\u5176\u5242\u91cf\uff0c\u5219\u5728\u6062\u590d\u81f3\u65e0\u75c7\u72b6\u6027\u5fc3\u52a8\u8fc7\u7f13\u6216\u5fc3\u7387\u226560bpm\u65f6\u6062\u590d\u4ee5\u524d\u5242\u91cf\u7684alectinib<\/li>\n\n\n\n<li>\u5982\u679c\u6ca1\u6709\u786e\u5b9a\u4f9b\u5e94\u7684\u4f34\u968f\u836f\u7269\uff0c\u6216\u8005\u5982\u679c\u4e0d\u505c\u6b62\u6216\u5242\u91cf\u6539\u53d8\u4f9b\u5e94\u7684\u4f34\u968f\u836f\u7269\uff0c\u6062\u590d\u65e0\u75c7\u72b6\u5fc3\u52a8\u8fc7\u7f13\u6216\u5fc3\u7387\u226560bpm\u65f6\uff0c\u4ee5\u51cf\u5c11\u7684\u5242\u91cf\u6062\u590dalectinib<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>\u5371\u53ca\u751f\u547d\u7684\u5fc3\u52a8\u8fc7\u7f13\u6216\u7d27\u6025\u5e72\u9884\u8868\u660e\n<ul class=\"wp-block-list\">\n<li>\u5982\u679c\u6ca1\u6709\u786e\u5b9a\u4f9b\u5e94\u7684\u4f34\u968f\u836f\u7269\uff0c\u5219\u6c38\u4e45\u505c\u836f<\/li>\n\n\n\n<li>\u5982\u679c\u786e\u5b9a\u5e76\u505c\u6b62\u4f9b\u5e94\u4f34\u968f\u836f\u7269\uff0c\u6216\u8005\u8c03\u6574\u5176\u5242\u91cf\uff0c\u5219\u5728\u6062\u590d\u81f3\u65e0\u75c7\u72b6\u6027\u5fc3\u52a8\u8fc7\u7f13\u6216\u5fc3\u7387\u226560bpm\u65f6\u4ee5\u51cf\u5c11\u7684\u5242\u91cf\u6062\u590dalectinib\uff0c\u5e76\u6839\u636e\u4e34\u5e8a\u6307\u793a\u8fdb\u884c\u9891\u7e41\u76d1\u6d4b<\/li>\n\n\n\n<li>\u5982\u679c\u518d\u6b21\u53d1\u751f\uff0c\u5c06\u6c38\u4e45\u505c\u6b62<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>CPK\u5347\u9ad8<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>CPK&gt; 5x ULN\uff1a\u6682\u65f6\u505c\u6b62\u76f4\u81f3\u6062\u590d\u81f3\u57fa\u7ebf\u6216\u22642.5xULN\uff0c\u7136\u540e\u4ee5\u76f8\u540c\u5242\u91cf\u6062\u590d<\/li>\n\n\n\n<li>CPK&gt; 10x ULN\u6216\u7b2c\u4e8c\u6b21\u51fa\u73b0&gt; 5x ULN\uff1a\u6682\u65f6\u505c\u6b62\u76f4\u81f3\u6062\u590d\u81f3\u57fa\u7ebf\u6216\u22642.5xULN\uff0c\u7136\u540e\u4ee5\u51cf\u5c11\u7684\u5242\u91cf\u6062\u590d<\/li>\n<\/ul>\n\n\n\n<p>\u80be\u529f\u80fd\u4e0d\u5168<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\uff1a\u65e0\u9700\u8c03\u6574\u5242\u91cf<\/li>\n\n\n\n<li>\u4e25\u91cd\uff08CrCl &lt;30 mL \/ min\uff09\u6216ESRD\uff1a\u672a\u7814\u7a76<\/li>\n<\/ul>\n\n\n\n<p>\u809d\u529f\u80fd\u635f\u5bb3<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8f7b\u5ea6\uff08TB\u2264ULN\u548cAST&gt; ULN\u6216TB&gt; 1-1.5x ULN\u548c\u4efb\u4f55AST\uff09\uff1a\u65e0\u9700\u8c03\u6574\u5242\u91cf<\/li>\n\n\n\n<li>\u4e2d\u5ea6\u81f3\u91cd\u5ea6\uff1a\u672a\u7814\u7a76<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u6ce8\u610f\u4e8b\u9879<\/h3>\n\n\n\n<p>\u5728\u6cbb\u7597\u524d\u5e94\u5bf9\u60a3\u8005\u8fdb\u884c\u6d4b\u8bd5\u5e76\u5448\u73b0ALK\u9633\u6027\u80bf\u7624<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e0d\u5229\u5f71\u54cd<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">&gt; 10\uff05\uff08\u6240\u6709\u7b49\u7ea7\uff09<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8d2b\u8840\uff0856\uff05\uff09<\/li>\n\n\n\n<li>AST\u589e\u52a0\uff0851\uff05\uff09<\/li>\n\n\n\n<li>\u78b1\u6027\u78f7\u9178\u9176\u589e\u52a0\uff0847\uff05\uff09<\/li>\n\n\n\n<li>\u589e\u52a0CPK\uff0843\uff05\uff09<\/li>\n\n\n\n<li>\u75b2\u52b3\uff0826-41\uff05\uff09<\/li>\n\n\n\n<li>\u9ad8\u80c6\u7ea2\u7d20\u8840\u75c7\uff0839\uff05\uff09<\/li>\n\n\n\n<li>\u9ad8\u8840\u7cd6\uff0836\uff05\uff09<\/li>\n\n\n\n<li>ALT\u589e\u52a0\uff0834\uff05\uff09<\/li>\n\n\n\n<li>\u4fbf\u79d8\uff0834\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u9499\u8840\u75c7\uff0832\uff05\uff09<\/li>\n\n\n\n<li>\u6c34\u80bf\uff0822-30\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u94be\u8840\u75c7\uff0829\uff05\uff09<\/li>\n\n\n\n<li>\u808c\u75db\uff0823-29\uff05\uff09<\/li>\n\n\n\n<li>\u808c\u9150\u589e\u52a0\uff0828\uff05\uff09<\/li>\n\n\n\n<li>\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\u75c7\uff0822\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u78f7\u8840\u75c7\uff0821\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u94a0\u8840\u75c7\uff0820\uff05\uff09<\/li>\n\n\n\n<li>\u54b3\u55fd\uff0819\uff05\uff09<\/li>\n\n\n\n<li>\u76ae\u75b9\uff0815-18\uff05\uff09<\/li>\n\n\n\n<li>\u6076\u5fc3\uff0814-18\uff05\uff09<\/li>\n\n\n\n<li>\u5934\u75db\uff0817\uff05\uff09<\/li>\n\n\n\n<li>\u8179\u6cfb\uff0812-16\uff05\uff09<\/li>\n\n\n\n<li>\u547c\u5438\u56f0\u96be\uff0816\uff05\uff09<\/li>\n\n\n\n<li>\u80cc\u75db\uff0812\uff05\uff09<\/li>\n\n\n\n<li>\u5455\u5410\uff087-12\uff05\uff09<\/li>\n\n\n\n<li>\u5fc3\u52a8\u8fc7\u7f13\uff0811\uff05\uff09<\/li>\n\n\n\n<li>\u4f53\u91cd\u589e\u52a0\uff0811\uff05\uff09<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">1-10\uff05\uff08\u6240\u6709\u7b49\u7ea7\uff09<\/h3>\n\n\n\n<p>\u89c6\u529b\u969c\u788d\uff0810\uff05\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">1-10\uff05\uff083\u5e74\u7ea7\u62164\u5e74\u7ea7\uff09<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>ALT\u589e\u52a0\uff084.8\uff05\uff09<\/li>\n\n\n\n<li>\u589e\u52a0CPK\uff084.6\uff05\uff09<\/li>\n\n\n\n<li>\u6dcb\u5df4\u7ec6\u80de\u51cf\u5c11\uff084.6\uff05\uff09<\/li>\n\n\n\n<li>\u89c6\u529b\u969c\u788d\uff084.6\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u94be\u8840\u75c7\uff084\uff05\uff09<\/li>\n\n\n\n<li>\u80be\u529f\u80fd\u635f\u5bb3\uff083.9\uff05\uff09<\/li>\n\n\n\n<li>\u547c\u5438\u56f0\u96be\uff083.6\uff05\uff09<\/li>\n\n\n\n<li>AST\u589e\u52a0\uff083.6\uff05\uff09<\/li>\n\n\n\n<li>Dysgeusia\uff083.3\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u78f7\u8840\u75c7\uff082.8\uff05\uff09<\/li>\n\n\n\n<li>\u9ad8\u80c6\u7ea2\u7d20\u8840\u75c7\uff082.4\uff05\uff09<\/li>\n\n\n\n<li>\u9ad8\u8840\u7cd6\uff082\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u94a0\u8840\u75c7\uff082\uff05\uff09<\/li>\n\n\n\n<li>\u8d2b\u8840\uff082\uff05\uff09<\/li>\n\n\n\n<li>\u75b2\u52b3\uff081.2\uff05\uff09<\/li>\n\n\n\n<li>\u808c\u75db\uff081.2\uff05\uff09<\/li>\n\n\n\n<li>\u8179\u6cfb\uff081.2\uff05\uff09<\/li>\n\n\n\n<li>\u78b1\u6027\u78f7\u9178\u9176\u589e\u52a0\uff081.2\uff05\uff09<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">&lt;1\uff05\uff083\u5e74\u7ea7\u62164\u5e74\u7ea7\uff09<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6c34\u80bf\uff080.7-0.8\uff05\uff09<\/li>\n\n\n\n<li>\u5934\u75db\uff080.8\uff05\uff09<\/li>\n\n\n\n<li>\u76ae\u75b9\uff080.4-0.7\uff05\uff09<\/li>\n\n\n\n<li>Dysgeusia\uff080.7\uff05\uff09<\/li>\n\n\n\n<li>\u6076\u5fc3\uff080.7\uff05\uff09<\/li>\n\n\n\n<li>\u5455\u5410\uff080.4\uff05\uff09<\/li>\n\n\n\n<li>\u91cd\u91cf\u589e\u52a0\uff080.4\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u9499\u8840\u75c7\uff080.4\uff05\uff09<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u6ce8\u610f\u4e8b\u9879<\/h3>\n\n\n\n<p>\u636e\u62a5\u9053\u809d\u9176\u5347\u9ad8;&nbsp;\u76d1\u6d4b\u809d\u529f\u80fd\u68c0\u67e5\uff0c\u5305\u62ecALT\uff0cAST\u548c\u603b\u80c6\u7ea2\u7d20\uff0c\u5728\u6cbb\u7597\u7684\u524d2\u4e2a\u6708\u5185\u8fdb\u884cq2\u5468\uff0c\u7136\u540e\u5728\u6cbb\u7597\u671f\u95f4\u5b9a\u671f\u8fdb\u884c\uff0c\u5bf9\u53d1\u751f\u8f6c\u6c28\u9176\u548c\u80c6\u7ea2\u7d20\u5347\u9ad8\u7684\u60a3\u8005\u8fdb\u884c\u66f4\u9891\u7e41\u7684\u68c0\u6d4b\uff08\u53c2\u89c1\u5242\u91cf\u8c03\u6574\uff09<\/p>\n\n\n\n<p>\u62a5\u544a\u95f4\u8d28\u6027\u80ba\u75c5\uff08ILD\uff09\u548c\u80ba\u708e;&nbsp;\u53ca\u65f6\u8c03\u67e5\u4efb\u4f55\u51fa\u73b0\u547c\u5438\u9053\u75c7\u72b6\u6076\u5316\uff08\u5982\u547c\u5438\u56f0\u96be\uff0c\u54b3\u55fd\uff0c\u53d1\u70e7\uff09\u7684\u60a3\u8005\uff0c\u5e76\u7acb\u5373\u505c\u6b62\u5bf9\u8bca\u65ad\u4e3aILD 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class=\"wp-block-heading\">\u6000\u5b55<\/h3>\n\n\n\n<p>\u6839\u636e\u52a8\u7269\u7814\u7a76\u53ca\u5176\u4f5c\u7528\u673a\u5236\uff0c\u7ed9\u5b55\u5987\u670d\u7528\u4f1a\u5bfc\u81f4\u80ce\u513f\u4f24\u5bb3\u6ca1\u6709\u5173\u4e8e\u6000\u5b55\u671f\u95f4\u4eba\u7c7b\u4f7f\u7528\u7684\u6570\u636e<\/p>\n\n\n\n<p>\u52a8\u7269\u6570\u636e<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5728\u5668\u5b98\u53d1\u751f\u671f\u95f4\u901a\u8fc7\u53e3\u670d\u7ba1\u9972\u7ed9\u4e88\u6000\u5b55\u5927\u9f20\u548c\u5154\u5b50\u5bfc\u81f4\u80da\u80ce \u2013 \u80ce\u513f\u6bd2\u6027\u548c\u6bcd\u4f53\u6bd2\u6027\u5242\u91cf\u7684\u6d41\u4ea7\uff0c\u66b4\u9732\u5927\u7ea6\u662f\u7528600mg BID\u7528alectinib\u6cbb\u7597\u7684\u4eba\u76842.7\u500d\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u907f\u5b55<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5973\u6027\uff1a\u5728\u6cbb\u7597\u671f\u95f4\u548c\u6700\u7ec8\u5242\u91cf\u540e1\u5468\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u63aa\u65bd<\/li>\n\n\n\n<li>\u7537\u6027\uff1a\u5728\u6cbb\u7597\u671f\u95f4\u548c\u6700\u7ec8\u5242\u91cf\u540e3\u4e2a\u6708\u4f7f\u7528\u6709\u6548\u7684\u907f\u5b55\u63aa\u65bd<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u54fa\u4e73\u671f<\/h3>\n\n\n\n<p>\u5982\u679c\u5206\u5e03\u5728\u4eba\u7c7b\u6bcd\u4e73\u4e2d\u5219\u4e0d\u660e\uff0c\u7531\u4e8e\u6765\u81eaalectinib\u7684\u6bcd\u4e73\u5582\u517b\u5a74\u513f\u53ef\u80fd\u53d1\u751f\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\uff0c\u5efa\u8bae\u54fa\u4e73\u671f\u5987\u5973\u5728\u6cbb\u7597\u671f\u95f4\u548c\u6700\u7ec8\u5242\u91cf\u540e1\u5468\u5185\u4e0d\u8981\u6bcd\u4e73\u5582\u517b\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u6000\u5b55\u7c7b\u522b<\/h3>\n\n\n\n<p>\u7b54\uff1a\u4e00\u822c\u53ef\u4ee5\u63a5\u53d7\u3002\u5b55\u5987\u7684\u5bf9\u7167\u7814\u7a76\u663e\u793a\u6ca1\u6709\u80ce\u513f\u98ce\u9669\u7684\u8bc1\u636e\u3002<\/p>\n\n\n\n<p>B\uff1a\u53ef\u4ee5\u63a5\u53d7\u3002\u52a8\u7269\u7814\u7a76\u663e\u793a\u6ca1\u6709\u98ce\u9669\uff0c\u4f46\u6ca1\u6709\u4eba\u7c7b\u7814\u7a76\u6216\u52a8\u7269\u7814\u7a76\u663e\u793a\u51fa\u8f7b\u5fae\u7684\u98ce\u9669\u548c\u4eba\u7c7b\u7814\u7a76\uff0c\u5e76\u4e14\u6ca1\u6709\u98ce\u9669\u3002<\/p>\n\n\n\n<p>C\uff1a\u5982\u679c\u6536\u76ca\u5927\u4e8e\u98ce\u9669\uff0c\u8bf7\u8c28\u614e\u4f7f\u7528\u3002\u52a8\u7269\u7814\u7a76\u663e\u793a\u98ce\u9669\u548c\u4eba\u4f53\u7814\u7a76\u4e0d\u53ef\u7528\uff0c\u6216\u52a8\u7269\u548c\u4eba\u7c7b\u7814\u7a76\u90fd\u6ca1\u6709\u3002<\/p>\n\n\n\n<p>D\uff1a\u5f53\u6ca1\u6709\u66f4\u5b89\u5168\u7684\u836f\u7269\u65f6\uff0c\u7528\u4e8e\u751f\u547d\u5371\u9669\u7684\u7d27\u6025\u60c5\u51b5\u3002\u4eba\u7c7b\u80ce\u513f\u98ce\u9669\u7684\u79ef\u6781\u8bc1\u636e\u3002<\/p>\n\n\n\n<p>X\uff1a\u4e0d\u8981\u5728\u6000\u5b55\u671f\u95f4\u4f7f\u7528\u3002\u6d89\u53ca\u7684\u98ce\u9669\u8d85\u8fc7\u4e86\u6f5c\u5728\u7684\u597d\u5904\u3002\u5b58\u5728\u66f4\u5b89\u5168\u7684\u66ff\u4ee3\u54c1\u3002<\/p>\n\n\n\n<p>NA\uff1a\u6ca1\u6709\u76f8\u5173\u4fe1\u606f\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u884c\u52a8\u673a\u5236<\/h3>\n\n\n\n<p>\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u9776\u5411ALK\u548cRET\u3002\u5728\u975e\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0calectinib\u6291\u5236ALK\u78f7\u9178\u5316\u548cALK\u4ecb\u5bfc\u7684\u4e0b\u6e38\u4fe1\u53f7\u86cb\u767dSTAT3\u548cAKT\u7684\u6d3b\u5316\uff0c\u5e76\u964d\u4f4e\u4e86\u643a\u5e26ALK\u878d\u5408\uff0c\u6269\u589e\u6216\u6fc0\u6d3b\u7a81\u53d8\u7684\u591a\u4e2a\u7ec6\u80de\u7cfb\u4e2d\u7684\u80bf\u7624\u7ec6\u80de\u6d3b\u529b\u3002alectinib\u7684\u4e3b\u8981\u6d3b\u6027\u4ee3\u8c22\u7269M4\u663e\u793a\u51fa\u76f8\u4f3c\u7684\u4f53\u5916\u6548\u529b\u548c\u6d3b\u6027\u3002Alectinib\u548cM4\u5728ALK\u9176\u7684\u591a\u79cd\u7a81\u53d8\u5f62\u5f0f\u4e2d\u8868\u73b0\u51fa\u4f53\u5916\u548c\u4f53\u5185\u6d3b\u6027\uff0c\u5305\u62ec\u5728\u514b\u5511\u66ff\u5c3c\u4e0a\u8fdb\u5c55\u7684\u60a3\u8005\u7684NSCLC\u80bf\u7624\u4e2d\u53d1\u73b0\u7684\u4e00\u4e9b\u7a81\u53d8\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5438\u6536<\/h3>\n\n\n\n<p>\u7edd\u5bf9\u751f\u7269\u5229\u7528\u5ea6\uff1a37\uff05\uff08\u542b\u98df\u7269\uff09<\/p>\n\n\n\n<p>\u7b49\u79bb\u5b50\u4f53\u5cf0\u503c\u65f6\u95f4\uff1a4\u5c0f\u65f6\uff08\u542b\u98df\u7269\uff09<\/p>\n\n\n\n<p>\u7a33\u6001\u5cf0\u503c\u8840\u6d46\u6d53\u5ea6\uff1a665 ng \/ mL;&nbsp;246 ng \/ mL\uff08M4\uff09<\/p>\n\n\n\n<p>AUC\uff1a7430 ng\u00b7h \/ mL;&nbsp;2810 ng\u00b7h \/ mL\uff08M4\uff09<\/p>\n\n\n\n<p>\u7a33\u6001\u8fbe\u5230\uff1a7\u5929<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5206\u914d<\/h3>\n\n\n\n<p>\u86cb\u767d\u8d28\u7ed3\u5408\uff08\u6bcd\u4f53\u836f\u7269\u548cM4\u4ee3\u8c22\u7269\uff09\uff1a&gt; 99\uff05<\/p>\n\n\n\n<p>Vd\uff1a4016\u5347;&nbsp;10,093\u5347\uff08M4\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u4ee3\u8c22<\/h3>\n\n\n\n<p>Alectinib\u88abCYP3A4\u4ee3\u8c22\u4e3a\u5176\u4e3b\u8981\u6d3b\u6027\u4ee3\u8c22\u7269M4<\/p>\n\n\n\n<p>\u968f\u540eM4\u88abCYP3A4\u4ee3\u8c22<\/p>\n\n\n\n<p>M4\u662fP-gp\u7684\u5e95\u7269<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u6d88\u9664<\/h3>\n\n\n\n<p>\u534a\u8870\u671f\uff1a33\u5c0f\u65f6;&nbsp;31\u5c0f\u65f6\uff08M4\uff09<\/p>\n\n\n\n<p>\u6e05\u9664\u7387\uff1a81.9\u5347\/\u5c0f\u65f6;&nbsp;217\u5347\/\u5c0f\u65f6\uff08M4\uff09<\/p>\n\n\n\n<p>\u6392\u6cc4<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7caa\u4fbf\uff1a84\uff05;&nbsp;6\uff05\uff08M4\uff09<\/li>\n\n\n\n<li>\u5c3f\u6db2\uff1a&lt;0.5\uff05<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u670d\u7528\u7ba1\u7406<\/h3>\n\n\n\n<p>\u548c\u98df\u7269\u540c\u670d\uff0c\u53e3\u670d\u6574\u4e2a\u80f6\u56ca\uff0c\u4e0d\u8981\u6253\u5f00\u6216\u6eb6\u89e3\u80f6\u56ca\u5185\u5bb9\u7269\u3002<\/p>\n\n\n\n<p>\u5982\u679c\u5242\u91cf\u9519\u8fc7\u6216\u5455\u5410\uff0c\u8bf7\u5728\u9884\u5b9a\u65f6\u95f4\u670d\u7528\u4e0b\u4e00\u5242\uff08\u4e0d\u8981\u670d\u7528\u989d\u5916\u5242\u91cf\uff09<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5b58\u50a8<\/h3>\n\n\n\n<p>\u4e0d\u8981\u50a8\u5b58\u572830\u00b0C\uff0886\u00b0F\uff09\u4ee5\u4e0a<\/p>\n\n\n\n<p>\u5b58\u653e\u5728\u5bb9\u5668\u4e2d\uff0c\u4ee5\u9632\u6b62\u5149\u7ebf\u548c\u6e7f\u6c14<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u9002\u5e94\u75c7\uff1a\u975e\u5c0f\u7ec6\u80de\u80ba\u764c 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