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\u800c\u80be\u75c5\u6cbb\u7597\u8fce\u6765\u91cd\u5927\u9769\u65b0\uff01\u5168\u7403\u9996\u521b\u53cc\u91cd\u9776\u5411\u80be\u75c5\u65b0\u836f\u2014\u2014\u65af\u5e15\u68ee\u5766\uff08Sparsentan\uff0c\u5546\u54c1\u540dFILSPARI\uff09<\/strong>\u7684\u4e0a\u5e02\uff0c\u7a81\u7834\u4e86\u4f20\u7edf\u6cbb\u7597\u7684\u8bf8\u591a\u5c40\u9650\u3002\u51ed\u501f\u72ec\u7279\u7684\u53cc\u91cd\u53d7\u4f53\u62ee\u6297\u673a\u5236\uff0c\u5b83\u517c\u5177\u964d\u86cb\u767d\u3001\u6297\u708e\u3001\u62a4\u80be\u3001\u6297\u7ea4\u7ef4\u5316\u591a\u91cd\u4f5c\u7528\uff0c\u662f\u8fd1\u5e74\u80be\u75c5\u9886\u57df\u6781\u5177\u7a81\u7834\u6027\u7684\u521b\u65b0\u836f\u7269\u3002\u4eca\u5929\uff0c\u6211\u4eec\u5c31\u5e26\u5927\u5bb6\u5168\u9762\u8bfb\u61c2\u8fd9\u6b3e\u96be\u6cbb\u6027\u80be\u75c5\u7684\u6838\u5fc3\u6cbb\u7597\u65b0\u836f\u3002<\/div>\n
\n
\"\u65af\u5e15\u68ee\u5766\"

\u65af\u5e15\u68ee\u5766<\/p><\/div>\n<\/div>\n

01\u3001\u4ec0\u4e48\u662f\u65af\u5e15\u68ee\u5766\uff1f\u5168\u65b0\u673a\u5236\u7684\u9996\u521b\u80be\u75c5\u9776\u5411\u836f<\/h2>\n
\u65af\u5e15\u68ee\u5766\u662f\u7f8e\u56fdTravere Therapeutics\u7814\u53d1\u7684\u5355\u5206\u5b50\u53cc\u91cd\u53d7\u4f53\u62ee\u6297\u5242<\/strong>\uff0c\u4e5f\u662f\u76ee\u524d\u5168\u7403\u552f\u4e00\u4e00\u6b3e\u540c\u65f6\u9776\u5411\u5185\u76ae\u7d20A\u578b\u53d7\u4f53\uff08ETA\uff09<\/strong>+<\/strong>\u8840\u7ba1\u7d27\u5f20\u7d20II 1\u578b\u53d7\u4f53\uff08AT1\uff09<\/strong>\u7684\u53e3\u670d\u5c0f\u5206\u5b50\u80be\u75c5\u65b0\u836f\uff0c\u548c\u4f20\u7edf\u5355\u4e00\u4f5c\u7528\u673a\u5236\u7684\u6c99\u5766\u3001\u666e\u5229\u7c7b\u836f\u7269\u6709\u7740\u672c\u8d28\u533a\u522b\u3002<\/div>\n
\u4f20\u7edf\u80be\u75c5\u836f\u7269\u5927\u591a\u53ea\u80fd\u5355\u4e00\u964d\u538b\u3001\u964d\u5c3f\u86cb\u767d\uff0c\u6cbb\u6807\u96be\u6cbb\u672c\u3002\u800c\u65af\u5e15\u68ee\u5766\u51ed\u501f\u201c\u4e00\u4e2a\u5206\u5b50\u3001\u53cc\u91cd\u901a\u8def\u201d\u7684\u72ec\u7279\u4f18\u52bf\uff0c\u7cbe\u51c6\u76f4\u51fb\u80be\u75c5\u8fdb\u5c55\u7684\u6838\u5fc3\u75c5\u7076\uff0c\u5b9e\u73b0\u4e861+1\uff1e2<\/strong>\u7684\u6cbb\u7597\u6548\u679c\uff0c\u4e13\u95e8\u89e3\u51b3\u4f20\u7edf\u6cbb\u7597\u65e0\u6548\u3001\u6548\u679c\u5dee\u3001\u75c5\u60c5\u53cd\u590d\u7684\u96be\u6cbb\u6027\u80be\u75c5\u96be\u9898\u3002<\/div>\n
\u8be5\u836f\u4e8e2023\u5e742\u6708\u83b7\u7f8e\u56fdFDA\u52a0\u901f\u6279\u51c6\u4e0a\u5e02\uff0c2026\u5e744\u6708\u6210\u529f\u62d3\u5c55\u65b0\u9002\u5e94\u75c7\uff0c\u4e34\u5e8a\u5e94\u7528\u8303\u56f4\u6301\u7eed\u6269\u5927\uff0c\u73b0\u5df2\u7eb3\u5165\u56fd\u9645\u6743\u5a01\u80be\u75c5\u8bca\u7597\u6307\u5357\uff0c\u6210\u4e3a\u96be\u6cbb\u6027\u80be\u75c5\u7684\u4f18\u9009\u6cbb\u7597\u65b9\u6848\u3002\u540c\u65f6\uff0c\u8001\u631d\u5362\u4fee\u65af\u5236\u836f\u63a8\u51fa\u5408\u89c4\u4eff\u5236\u7248\u672cLuciSeta\uff0c\u5927\u5e45\u964d\u4f4e\u7528\u836f\u6210\u672c\uff0c\u8ba9\u666e\u901a\u60a3\u8005\u4e5f\u80fd\u5e73\u4ef7\u7528\u4e0a\u8fd9\u6b3e\u9ad8\u7aef\u521b\u65b0\u836f\u3002<\/div>\n

02\u3001\u6838\u5fc3\u4f5c\u7528\u673a\u5236\uff1a\u53cc\u91cd\u963b\u65ad\uff0c\u5168\u65b9\u4f4d\u5b88\u62a4\u80be\u810f<\/h2>\n
\u5f88\u591a\u60a3\u8005\u7591\u60d1\uff0c\u4e3a\u4f55\u4f20\u7edf\u836f\u7269\u96be\u4ee5\u963b\u65ad\u80be\u75c5\u6076\u5316\uff1f\u6838\u5fc3\u539f\u56e0\u5728\u4e8e\u6162\u6027\u80be\u75c5\u7684\u8fdb\u5c55\uff0c\u4f9d\u8d56\u4e24\u5927\u5173\u952e\u81f4\u75c5\u901a\u8def\uff1a\u8840\u7ba1\u7d27\u5f20\u7d20II\u901a\u8def\u4e0e\u5185\u76ae\u7d20\u901a\u8def\u3002\u4e24\u6761\u901a\u8def\u5f02\u5e38\u6fc0\u6d3b\u540e\uff0c\u4f1a\u6301\u7eed\u5f15\u53d1\u80be\u810f\u8840\u7ba1\u6536\u7f29\u3001\u80be\u5c0f\u7403\u635f\u4f24\u3001\u6162\u6027\u708e\u75c7\u6d78\u6da6\u53ca\u80be\u810f\u7ea4\u7ef4\u5316\uff0c\u76f4\u63a5\u5bfc\u81f4\u5c3f\u86cb\u767d\u5c45\u9ad8\u4e0d\u4e0b\uff0c\u80be\u529f\u80fd\u51fa\u73b0\u4e0d\u53ef\u9006\u8870\u9000\u3002<\/div>\n
\u65af\u5e15\u68ee\u5766\u7684\u6838\u5fc3\u4f18\u52bf\uff0c\u5c31\u662f\u540c\u65f6\u963b\u65ad\u4e24\u5927\u81f4\u75c5\u901a\u8def<\/strong>\uff0c\u4ece\u6839\u6e90\u904f\u5236\u80be\u75c5\u6076\u5316\uff1a<\/div>\n
1\u3001\u963b\u65adAT1\u53d7\u4f53\uff08\u8840\u7ba1\u7d27\u5f20\u7d20\u901a\u8def\uff09<\/strong> \u7cbe\u51c6\u6291\u5236\u8840\u7ba1\u7d27\u5f20\u7d20\u7684\u81f4\u75c5\u6548\u5e94\uff0c\u6269\u5f20\u80be\u810f\u8840\u7ba1\u3001\u964d\u4f4e\u80be\u5c0f\u7403\u5185\u9ad8\u538b\uff0c\u4ece\u6839\u6e90\u51cf\u5c11\u86cb\u767d\u6e17\u6f0f\uff0c\u5feb\u901f\u5e73\u7a33\u964d\u4f4e\u5c3f\u86cb\u767d\uff0c\u51cf\u8f7b\u80be\u810f\u4ee3\u8c22\u8d1f\u8377\uff0c\u6709\u6548\u89e3\u51b3\u86cb\u767d\u5c3f\u53cd\u590d\u96be\u9898\u3002<\/div>\n
2\u3001\u963b\u65adETA\u53d7\u4f53\uff08\u5185\u76ae\u7d20\u901a\u8def\uff09<\/strong> \u5f3a\u6548\u6291\u5236\u80be\u810f\u6162\u6027\u708e\u75c7\uff0c\u4fdd\u62a4\u80be\u5c0f\u7403\u8db3\u7ec6\u80de\u8fd9\u4e00\u6838\u5fc3\u6ee4\u8fc7\u7ed3\u6784\uff0c\u7cbe\u51c6\u963b\u65ad\u80be\u810f\u7ea4\u7ef4\u5316\u8fdb\u7a0b\uff0c\u9632\u6b62\u80be\u7ec4\u7ec7\u786c\u5316\u574f\u6b7b\uff0c\u4ece\u6839\u672c\u4e0a\u5ef6\u7f13\u3001\u904f\u5236\u80be\u529f\u80fd\u8870\u9000\u3002<\/div>\n
\u53cc\u91cd\u901a\u8def\u534f\u540c\u8d77\u6548\uff0c\u8865\u9f50\u4e86\u4f20\u7edf\u836f\u7269\u201c\u4ec5\u964d\u86cb\u767d\u3001\u65e0\u6297\u708e\u6297\u7ea4\u7ef4\u5316\u4f5c\u7528\u201d\u7684\u77ed\u677f\uff0c\u5b9e\u73b0\u964d\u5c3f\u86cb\u767d\u3001\u63a7\u80be\u810f\u708e\u75c7\u3001\u963b\u80be\u7ea4\u7ef4\u5316\u3001\u4fdd\u6b8b\u4f59\u80be\u529f\u80fd<\/strong>\u56db\u91cd\u7597\u6548\uff0c\u771f\u6b63\u505a\u5230\u6807\u672c\u517c\u6cbb\uff0c\u5168\u65b9\u4f4d\u4fdd\u62a4\u80be\u810f\u3002<\/div>\n

03\u3001\u7cbe\u51c6\u9002\u914d\u4eba\u7fa4\uff1a\u4e24\u5927\u6838\u5fc3\u9002\u5e94\u75c7\uff0c\u8986\u76d6\u96be\u6cbb\u80be\u75c5<\/h2>\n
\u7ecf\u591a\u9879\u5168\u7403\u5927\u578b\u4e09\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9a8c\u8bc1\uff0c\u65af\u5e15\u68ee\u5766\u7597\u6548\u5b89\u5168\u3001\u786e\u5207\uff0c\u76ee\u524d\u4e3b\u8981\u7528\u4e8e\u6cbb\u7597\u4e24\u7c7b\u9ad8\u53d1\u3001\u96be\u6cbb\u7684\u6210\u4eba\u80be\u75c5\uff0c\u7cbe\u51c6\u8986\u76d6\u4e34\u5e8a\u4e3b\u6d41\u7591\u96be\u80be\u75c5\u4eba\u7fa4\uff1a<\/div>\n
1. \u539f\u53d1\u6027IgA\u80be\u75c5\uff08\u6210\u4eba\uff09<\/strong><\/div>\n
\u9002\u7528\u4e8e\u5b58\u5728\u75c5\u60c5\u5feb\u901f\u8fdb\u5c55\u98ce\u9669\u3001\u5c3f\u86cb\u767d\u808c\u9150\u6bd4\u503c\uff08UPCR\uff09\u22651.5g\/g\u7684\u6210\u4eba\u60a3\u8005\u3002IgA\u80be\u75c5\u662f\u6211\u56fd\u9ad8\u53d1\u7684\u539f\u53d1\u6027\u80be\u5c0f\u7403\u75be\u75c5\uff0c\u591a\u6570\u60a3\u8005\u75c5\u60c5\u8fc1\u5ef6\u4e0d\u6108\uff0c10-20\u5e74\u5185\u5927\u6982\u7387\u8fdb\u5c55\u4e3a\u5c3f\u6bd2\u75c7\u3002\u4e34\u5e8a\u6570\u636e\u663e\u793a\uff0c\u65af\u5e15\u68ee\u5766\u53ef\u957f\u6548\u3001\u6df1\u5ea6\u964d\u4f4e\u5c3f\u86cb\u767d\uff0c\u7a33\u5b9a\u80be\u529f\u80fd\uff0c\u663e\u8457\u964d\u4f4e\u7ec8\u672b\u671f\u80be\u75c5\u53d1\u75c5\u98ce\u9669\u3002<\/div>\n
2. \u5c40\u7076\u8282\u6bb5\u6027\u80be\u5c0f\u7403\u786c\u5316\u75c7\uff08FSGS\uff09<\/strong><\/div>\n
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04\u3001\u4e34\u5e8a\u6838\u5fc3\u4f18\u52bf\uff1a\u5b8c\u80dc\u4f20\u7edf\u65b9\u6848\u7684\u56db\u5927\u4eae\u70b9<\/h2>\n
\u5bf9\u6bd4\u6c99\u5766\u3001\u666e\u5229\u3001\u6fc0\u7d20\u3001\u514d\u75ab\u6291\u5236\u5242\u7b49\u4f20\u7edf\u80be\u75c5\u6cbb\u7597\u65b9\u6848\uff0c\u65af\u5e15\u68ee\u5766\u7684\u4f18\u52bf\u5341\u5206\u663e\u8457\uff0c\u4e5f\u662f\u5b83\u6210\u4e3a\u96be\u6cbb\u80be\u75c5\u4e00\u7ebf\u65b0\u836f\u7684\u6838\u5fc3\u539f\u56e0\uff1a<\/div>\n
1. \u7597\u6548\u66f4\u5f3a\uff0c\u964d\u86cb\u767d\u6548\u679c\u66f4\u6301\u4e45<\/strong><\/div>\n
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2. \u53cc\u91cd\u62a4\u80be\uff0c\u963b\u65ad\u75c5\u60c5\u8fdb\u5c55\u66f4\u5f7b\u5e95<\/strong><\/div>\n
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3. \u6446\u8131\u6fc0\u7d20\u4f9d\u8d56\uff0c\u5b89\u5168\u6027\u66f4\u9ad8<\/strong><\/div>\n
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05\u3001\u7528\u836f\u5173\u952e\u987b\u77e5\uff1a\u5b89\u5168\u7528\u836f\uff0c\u89c4\u907f\u98ce\u9669<\/h2>\n
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2\u3001\u660e\u786e\u7981\u5fcc\u4eba\u7fa4<\/strong>\uff1a\u5b55\u671f\u3001\u5907\u5b55\u671f\u5973\u6027\uff0c\u4ee5\u53ca\u91cd\u5ea6\u809d\u80be\u529f\u80fd\u8870\u7aed\u60a3\u8005\u7981\u6b62\u4f7f\u7528\uff0c\u907f\u514d\u5f15\u53d1\u4e25\u91cd\u5b89\u5168\u98ce\u9669\u3002<\/div>\n
3\u3001\u5b9a\u671f\u590d\u67e5\u76d1\u6d4b\u6307\u6807<\/strong>\uff1a\u7528\u836f\u671f\u95f4\u9700\u5b9a\u671f\u590d\u67e5\u8840\u538b\u3001\u809d\u80be\u529f\u80fd\u3001\u8840\u94be\u3001\u5c3f\u86cb\u767d\u7b49\u6838\u5fc3\u6307\u6807\uff0c\u7531\u4e13\u4e1a\u80be\u75c5\u533b\u751f\u6839\u636e\u590d\u67e5\u6570\u636e\u52a8\u6001\u8c03\u6574\u7528\u836f\u65b9\u6848\u3002<\/div>\n
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06\u3001\u603b\u7ed3\uff1a\u96be\u6cbb\u6027\u80be\u75c5\u60a3\u8005\u7684\u5168\u65b0\u5e0c\u671b<\/h2>\n
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