{"id":856,"date":"2026-05-23T18:45:37","date_gmt":"2026-05-23T10:45:37","guid":{"rendered":"https:\/\/yaozhiyou.com\/?p=856"},"modified":"2026-05-23T18:47:16","modified_gmt":"2026-05-23T10:47:16","slug":"%e6%8b%89%e7%bd%97%e6%9b%bf%e5%b0%bc%ef%bc%9a%e5%b9%bf%e8%b0%b1%e6%8a%97%e7%99%8c-%e7%a5%9e%e8%8d%af%ef%bc%8c%e5%8e%9f%e7%a0%94%e5%a4%aa%e8%b4%b5%ef%bc%9f%e4%bb%bf%e5%88%b6%e8%8d%af","status":"publish","type":"post","link":"https:\/\/yaozhiyou.com\/?p=856","title":{"rendered":"\u62c9\u7f57\u66ff\u5c3c\uff1a\u5e7f\u8c31\u6297\u764c \u201c\u795e\u836f\u201d\uff0c\u539f\u7814\u592a\u8d35\uff1f\u4eff\u5236\u836f\u600e\u4e48\u9009\uff1f"},"content":{"rendered":"

\u5728\u764c\u75c7\u7cbe\u51c6\u6cbb\u7597\u65f6\u4ee3\uff0c\u4e00\u6b3e\u836f\u80fd\u6cbb 17 \u79cd\u764c\u75c7\uff0c\u4f60\u6562\u4fe1\uff1f\u5b83\u5c31\u662f\u62c9\u7f57\u66ff\u5c3c\uff08Larotrectinib\uff0c\u5546\u54c1\u540d\uff1a\u7ef4\u6cf0\u51ef\uff09\uff0c\u5168\u7403\u9996\u6b3e \u201c\u4e0d\u9650\u764c\u79cd\u201d \u7684\u5e7f\u8c31\u9776\u5411\u836f\uff0c\u51ed\u501f\u5bf9 NTRK \u57fa\u56e0\u878d\u5408\u7684\u7cbe\u51c6\u6253\u51fb\uff0c\u4e3a\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u6253\u5f00\u4e86\u957f\u671f\u751f\u5b58\u7684\u65b0\u5927\u95e8\u3002\u4f46\u539f\u7814\u836f\u5929\u4ef7\u8ba9\u591a\u6570\u60a3\u8005\u671b\u800c\u5374\u6b65\uff0c\u8001\u631d\u3001\u5b5f\u52a0\u62c9\u3001\u5370\u5ea6\u7b49\u5730\u7684\u4eff\u5236\u836f\u5e94\u8fd0\u800c\u751f\uff0c\u6210\u4e3a\u6027\u4ef7\u6bd4\u4e4b\u9009\u3002\u4eca\u5929\u4e00\u6587\u8bb2\u6e05\u62c9\u7f57\u66ff\u5c3c\u7684\u7597\u6548\u3001\u539f\u7814\u4e0e\u4eff\u5236\u836f\u5dee\u5f02\u3001\u4ef7\u683c\u5bf9\u6bd4\u53ca\u907f\u5751\u6307\u5357\uff01
\n\u4e00\u3001\u62c9\u7f57\u66ff\u5c3c\uff1a\u764c\u75c7\u6cbb\u7597\u7684 \u201c\u91cc\u7a0b\u7891\u5f0f\u836f\u7269\u201d
\n1. \u4ec0\u4e48\u662f\u62c9\u7f57\u66ff\u5c3c\uff1f
\n\u62c9\u7f57\u66ff\u5c3c\u7531\u62dc\u8033\u4e0e Loxo Oncology \u8054\u5408\u7814\u53d1\uff0c\u662f\u7b2c\u4e00\u4ee3\u9ad8\u9009\u62e9\u6027 TRK \u6291\u5236\u5242\uff0c\u6838\u5fc3\u9488\u5bf9NTRK1\/2\/3 \u57fa\u56e0\u878d\u5408\u7a81\u53d8\u3002\u7b80\u5355\u8bf4\uff1a\u4e0d\u7ba1\u80bf\u7624\u957f\u5728\u80ba\u3001\u7532\u72b6\u817a\u3001\u4e73\u817a\u8fd8\u662f\u7ed3\u76f4\u80a0\uff0c\u53ea\u8981\u68c0\u6d4b\u51fa NTRK \u878d\u5408\uff0c\u5c31\u80fd\u7528\u5b83\u6cbb\u7597\uff0c\u771f\u6b63\u5b9e\u73b0 \u201c\u53ea\u770b\u7a81\u53d8\uff0c\u4e0d\u770b\u764c\u79cd\u201d\u3002<\/p>\n

\"\u62c9\u7f57\u66ff\u5c3c\"<\/p>\n

2. \u7597\u6548\u6709\u591a\u786c\u6838\uff1f
\n\u8986\u76d6\u764c\u79cd\uff1a17 \u79cd\u5b9e\u4f53\u7624\uff0c\u5305\u62ec\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u7532\u72b6\u817a\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u4e73\u817a\u764c\u3001\u8089\u7624\u7b49\u3002
\n\u6709\u6548\u7387\uff08ORR\uff09\uff1a\u6574\u4f5375% \u4ee5\u4e0a\uff0c\u7532\u72b6\u817a\u764c 81%\u3001\u80ba\u764c 73%\u3001\u7ed3\u76f4\u80a0\u764c 67%\uff0c\u591a\u6570\u60a3\u8005\u7528\u836f\u540e\u80bf\u7624\u660e\u663e\u7f29\u5c0f\u751a\u81f3\u6d88\u5931\u3002
\n\u7597\u6548\u6301\u4e45\uff1a\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u8d853 \u5e74\uff0c\u90e8\u5206\u60a3\u8005\u5b9e\u73b0\u4e34\u5e8a\u6cbb\u6108\u3002
\n\u9002\u7528\u4eba\u7fa4\uff1a\u6210\u4eba \/ \u513f\u7ae5\u5747\u53ef\uff0c\u7528\u4e8e\u5c40\u90e8\u665a\u671f\u3001\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\uff0c\u6216\u672f\u540e\u6613\u590d\u53d1\u3001\u65e0\u66ff\u4ee3\u65b9\u6848\u7684\u60a3\u8005\u3002
\n3. \u539f\u7814\u836f\u4ef7\u683c\uff1a\u5929\u4ef7\u95e8\u69db\uff0c\u591a\u6570\u60a3\u8005\u7528\u4e0d\u8d77
\n\u56fd\u5185\u539f\u7814\uff08\u7ef4\u6cf0\u51ef\uff09\u5df2\u7eb3\u5165\u533b\u4fdd\uff0c100mg\u00d730 \u7c92 \/ \u76d2\uff0c\u533b\u4fdd\u540e 31500 \u5143\uff0c\u6708\u5747\u81ea\u4ed8 4000-8000 \u5143\uff08\u62a5\u9500\u6bd4\u4f8b 30%-50%\uff09\u3002\u672a\u533b\u4fdd\u65f6\uff0c\u5e74\u8d39\u7528\u8d8560 \u4e07\u5143\uff1b\u7f8e\u56fd\u539f\u7814\u6708\u8d39\u7ea6 32800 \u7f8e\u5143\uff08\u2248260 \u4e07\u4eba\u6c11\u5e01\uff09\uff0c\u582a\u79f0 \u201c\u5929\u4ef7\u201d\u3002
\n\u4e8c\u3001\u62c9\u7f57\u66ff\u5c3c\u4eff\u5236\u836f\uff1a\u5e73\u4ef7\u66ff\u4ee3\uff0c\u7597\u6548\u7b49\u6548
\n1. \u4eff\u5236\u836f\u662f\u4ec0\u4e48\uff1f\u5408\u6cd5\u5417\uff1f
\n\u4eff\u5236\u836f\u662f\u539f\u7814\u836f\u4e13\u5229\u5230\u671f\u524d\uff0c\u7ecf\u5f53\u5730\u836f\u76d1\u90e8\u95e8\u6279\u51c6\u751f\u4ea7\u7684 \u201c\u7b49\u540c\u836f\u201d\uff0c\u6838\u5fc3\u6210\u5206\u3001\u7597\u6548\u3001\u5b89\u5168\u6027\u4e0e\u539f\u7814\u4e00\u81f4\uff0c\u4e14\u65e0\u9700\u627f\u62c5\u7814\u53d1\u6210\u672c\uff0c\u4ef7\u683c\u4ec5\u4e3a\u539f\u7814\u7684 3%-9%\u3002\u76ee\u524d\u4e3b\u6d41\u5408\u6cd5\u7248\u672c\u6765\u81ea\u8001\u631d\u3001\u5b5f\u52a0\u62c9\u3001\u5370\u5ea6\uff0c\u5747\u83b7\u5f53\u5730\u836f\u76d1\u8ba4\u8bc1\uff0c\u7b26\u5408\u56fd\u9645 GMP \u6807\u51c6\u3002
\n2. \u4e3b\u6d41\u4eff\u5236\u836f\u7248\u672c\u5bf9\u6bd4\uff082026 \u5e74 5 \u6708\u6700\u65b0\uff09<\/p>\n\n\n\n\n\n\n\n\n\n\n
\u7248\u672c<\/th>\n\u751f\u4ea7\u5382\u5bb6<\/th>\n\u89c4\u683c<\/th>\n\u4ef7\u683c\uff08\u5143 \/ \u76d2\uff09<\/th>\n\u6708\u8d39\u7528\uff08\u5143\uff09<\/th>\n\u4f18\u52bf<\/th>\n<\/tr>\n<\/thead>\n
\u8001\u631d\u5362\u4fee\u65af<\/td>\nLucius<\/td>\n100mg\u00d730 \u7c92<\/td>\n<\/td>\n<\/td>\n\u5168\u7403\u6700\u4f4e\u4ef7<\/strong>\uff0c\u9632\u4f2a\u5b8c\u5584<\/td>\n<\/tr>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

\"\"<\/picture>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n
\n
\"4\"

4<\/p><\/div>\n<\/div>\n<\/div>\n<\/div>\n

<\/div>\n<\/div>\n<\/td>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u8001\u631d\u4e1c\u76df<\/td>\n\u4e1c\u76df\u5236\u836f<\/td>\n100mg\u00d730 \u7c92<\/td>\n<\/td>\n<\/td>\n\u4e0a\u5e02\u65e9\uff0c\u53e3\u7891\u7a33\u5b9a<\/td>\n<\/tr>\n
\u5b5f\u52a0\u62c9\u73e0\u5cf0<\/td>\nEverest<\/td>\n100mg\u00d730 \u7c92<\/td>\n<\/td>\n<\/td>\nDGDA \u8ba4\u8bc1\uff0c\u7597\u6548\u7b49\u6548\u6027 98%<\/td>\n<\/tr>\n
\n
\n
\n
\n
\n
\n
\n
\n
\n

\"\"<\/picture>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n
\"3\"<\/div>\n<\/div>\n<\/div>\n
<\/div>\n<\/div>\n<\/td>\n
<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
\u5370\u5ea6 Cipla<\/td>\nCipla<\/td>\n100mg\u00d730 \u7c92<\/td>\n<\/td>\n<\/td>\n\u5927\u5382\u751f\u4ea7\uff0c\u8d28\u91cf\u7a33\u5b9a<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

3. \u4eff\u5236\u836f vs \u539f\u7814\u836f\uff1a\u6838\u5fc3\u5dee\u5f02
\n\u7597\u6548\uff1a\u5b8c\u5168\u7b49\u6548\uff0c\u4eff\u5236\u836f\u4e34\u5e8a ORR \u540c\u6837\u8fbe 75% \u4ee5\u4e0a\uff0c\u6570\u636e\u4e0e\u539f\u7814\u9ad8\u5ea6\u543b\u5408\u3002
\n\u5b89\u5168\u6027\uff1a\u526f\u4f5c\u7528\u4e00\u81f4\uff0c\u5e38\u89c1\u8f7b\u5fae\u6076\u5fc3\u3001\u75b2\u52b3\u3001\u5934\u6655\uff0c\u65e0\u4e25\u91cd\u4e0d\u53ef\u9006\u6bd2\u6027\u3002
\n\u4ef7\u683c\uff1a\u4eff\u5236\u836f\u5e74\u8d39\u75282.3 \u4e07 – 5.4 \u4e07\u5143\uff0c\u539f\u7814\u5e74\u8d39\u7528\u8d85 60 \u4e07\uff0c\u5e74\u7701 57 \u4e07 +\u3002
\n\u6210\u5206\uff1a\u6838\u5fc3\u6d3b\u6027\u6210\u5206\u4e00\u81f4\uff0c\u4ec5\u8f85\u6599\u3001\u751f\u4ea7\u5de5\u827a\u7565\u6709\u5dee\u5f02\uff0c\u4e0d\u5f71\u54cd\u7597\u6548\u3002
\n\u4e09\u3001\u4eff\u5236\u836f\u8d2d\u4e70\uff1a\u907f\u5751\u5fc5\u770b\uff0c\u8fdc\u79bb\u5047\u836f
\n1. 3 \u5927\u771f\u4f2a\u9274\u522b\u65b9\u6cd5
\n\u5305\u88c5\u9a8c\u8bc1\uff1a\u6b63\u54c1\u5370\u5237\u6e05\u6670\uff0c\u65e0\u91cd\u5f71\uff1b\u6279\u53f7\u3001\u6709\u6548\u671f\u6fc0\u5149\u96d5\u523b\uff0c\u522e\u4e0d\u6389\uff1b\u8001\u631d \/ \u5b5f\u52a0\u62c9\u7248\u6709\u5168\u606f\u9632\u4f2a\u6807\uff0c\u503e\u659c\u53ef\u89c1\u836f\u76d1 logo \u52a8\u6001\u53d8\u5316\u3002
\n\u8d44\u8d28\u67e5\u8be2\uff1a\u8981\u6c42\u63d0\u4f9b\u836f\u54c1\u6ce8\u518c\u8bc1\u53f7\uff0c\u767b\u5f55\u5f53\u5730\u836f\u76d1\u5b98\u7f51\uff08\u5982\u5b5f\u52a0\u62c9 DGDA\u3001\u8001\u631d FDA\uff09\u53ef\u67e5\u751f\u4ea7\u4fe1\u606f\uff0c\u65e0\u8bb0\u5f55\u5373\u5047\u836f\u3002
\n\u6e20\u9053\u6eaf\u6e90\uff1a\u6b63\u54c1\u6709\u539f\u5382\u7269\u6d41\u7801\uff0c\u626b\u7801\u53ef\u67e5\u6279\u6b21\u3001\u51fa\u53e3\u65e5\u671f\uff1b\u6b63\u89c4\u6e20\u9053\u63d0\u4f9b\u76f4\u90ae\u7269\u6d41\u5355\uff0c\u59cb\u53d1\u5730\u4e3a\u8001\u631d\u4e07\u8c61\u3001\u5b5f\u52a0\u62c9\u8fbe\u5361\u3002
\n2. \u7edd\u5bf9\u907f\u5f00 3 \u7c7b\u9ad8\u5371\u6e20\u9053
\n\u4e2a\u4eba\u4ee3\u8d2d\uff1a\u65e0\u8d44\u8d28\uff0c\u5047\u836f\u7387\u8d85 80%\uff0c\u65e0\u552e\u540e\uff0c\u7ef4\u6743\u96be\u3002
\n\u4f4e\u4ef7 \u201c\u4e09\u65e0\u201d \u836f\uff1a\u4ef7\u683c\u4f4e\u4e8e 1500 \u5143 \/ \u76d2\uff0c\u65e0\u5305\u88c5\u3001\u65e0\u6279\u53f7\u3001\u65e0\u9632\u4f2a\uff0c100% \u5047\u836f\u3002
\n\u56fd\u5185 \u201c\u73b0\u8d27\u201d\uff1a\u62c9\u7f57\u66ff\u5c3c\u4eff\u5236\u836f\u672a\u5728\u56fd\u5185\u83b7\u6279\uff0c\u56fd\u5185\u73b0\u8d27\u5747\u4e3a\u975e\u6cd5\u8d70\u79c1\uff0c\u98ce\u9669\u6781\u9ad8\u3002
\n3. \u5408\u6cd5\u8d2d\u4e70\u6d41\u7a0b
\n\u57fa\u56e0\u68c0\u6d4b\uff1a\u786e\u8bcaNTRK \u878d\u5408\u9633\u6027\uff08\u5fc5\u987b\uff0c\u5426\u5219\u65e0\u6548\uff09\u3002
\n\u54a8\u8be2\u533b\u751f\uff1a\u8bc4\u4f30\u8eab\u4f53\u72b6\u51b5\uff0c\u786e\u8ba4\u9002\u7528\u62c9\u7f57\u66ff\u5c3c\uff0c\u5236\u5b9a\u7528\u836f\u65b9\u6848\u3002
\n\u6b63\u89c4\u6e20\u9053\uff1a\u9009\u62e9\u6709\u8d44\u8d28\u7684\u8de8\u5883\u533b\u7597\u5e73\u53f0\uff0c\u7b7e\u8ba2\u5408\u540c\uff0c\u63d0\u4f9b\u75c5\u5386 \/ \u68c0\u6d4b\u62a5\u544a\u3002
\n\u539f\u5382\u76f4\u90ae\uff1a\u836f\u54c1\u4ece\u8001\u631d \/ \u5b5f\u52a0\u62c9 \/ \u5370\u5ea6\u539f\u5382\u76f4\u63a5\u90ae\u5bc4\uff0c\u5168\u7a0b\u53ef\u6eaf\u6e90\uff0c\u675c\u7edd\u5047\u8d27\u3002
\n\u56db\u3001\u603b\u7ed3\uff1a\u7cbe\u51c6\u7528\u836f\uff0c\u6027\u4ef7\u6bd4\u4e3a\u738b
\n\u62c9\u7f57\u66ff\u5c3c\u7684\u51fa\u73b0\uff0c\u8ba9 NTRK \u878d\u5408\u9633\u6027\u665a\u671f\u764c\u75c7\u60a3\u8005\u770b\u5230\u957f\u671f\u751f\u5b58\u5e0c\u671b\uff0c\u4f46\u539f\u7814\u836f\u9ad8\u4ef7\u8ba9\u591a\u6570\u60a3\u8005\u96be\u4ee5\u8d1f\u62c5\u3002\u6b63\u89c4\u4eff\u5236\u836f\u662f\u76ee\u524d\u6700\u5177\u6027\u4ef7\u6bd4\u7684\u9009\u62e9\uff0c\u7597\u6548\u4e0e\u539f\u7814\u4e00\u81f4\uff0c\u4ef7\u683c\u4ec5\u4e3a\u539f\u7814\u7684\u96f6\u5934\uff0c\u5e74\u7701\u51e0\u5341\u4e07\uff0c\u6781\u5927\u51cf\u8f7b\u5bb6\u5ead\u8d1f\u62c5\u3002
\n\u6700\u540e\u63d0\u9192\uff1a\u7528\u836f\u524d\u5fc5\u987b\u505a NTRK \u57fa\u56e0\u68c0\u6d4b\uff0c\u9634\u6027\u7528\u4e86\u65e0\u6548\uff1b\u52a1\u5fc5\u901a\u8fc7\u6b63\u89c4\u6e20\u9053\u8d2d\u836f\uff0c\u8fdc\u79bb\u5047\u836f\uff0c\u5b89\u5168\u7528\u836f\u624d\u662f\u751f\u5b58\u5173\u952e\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"

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