{"id":833,"date":"2026-05-19T10:15:01","date_gmt":"2026-05-19T02:15:01","guid":{"rendered":"https:\/\/www.yaozhiyou.com\/?p=833"},"modified":"2026-05-19T10:15:01","modified_gmt":"2026-05-19T02:15:01","slug":"%e6%99%ae%e6%8b%89%e6%9b%bf%e5%b0%bc%ef%bc%88pralsetinib%ef%bc%8c%e5%95%86%e5%93%81%e5%90%8d%ef%bc%9a%e6%99%ae%e5%90%89%e5%8d%8e-gavreto%ef%bc%89","status":"publish","type":"post","link":"https:\/\/yaozhiyou.com\/?p=833","title":{"rendered":"\u666e\u62c9\u66ff\u5c3c\uff08Pralsetinib\uff0c\u5546\u54c1\u540d\uff1a\u666e\u5409\u534e \u00ae\/Gavreto\u00ae\uff09"},"content":{"rendered":"<p>\u666e\u62c9\u66ff\u5c3c\uff08Pralsetinib\uff0c\u5546\u54c1\u540d\uff1a\u666e\u5409\u534e \u00ae\/Gavreto\u00ae\uff09\u662f\u9ad8\u9009\u62e9\u6027 RET \u9776\u5411\u836f\uff0c\u6838\u5fc3\u7528\u4e8eRET \u878d\u5408\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u4e0eRET \u7a81\u53d8 \/ \u878d\u5408\u7532\u72b6\u817a\u764c\uff0c2021 \u5e74 3 \u6708\u4e2d\u56fd\u83b7\u6279\uff0c2023 \u5e74 6 \u6708\u65b0\u589e\u4e00\u7ebf\u9002\u5e94\u75c7\uff0c\u533b\u4fdd\u4e59\u7c7b\u3002<\/p>\n<div id=\"attachment_834\" style=\"width: 810px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-834\" class=\"size-full wp-image-834\" title=\"\u666e\u62c9\u66ff\u5c3c\u80f6\u56ca\" src=\"https:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u666e\u62c9\u66ff\u5c3c\u80f6\u56ca.jpg\" alt=\"\u666e\u62c9\u66ff\u5c3c\u80f6\u56ca\" width=\"800\" height=\"512\" srcset=\"https:\/\/yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u666e\u62c9\u66ff\u5c3c\u80f6\u56ca.jpg 800w, https:\/\/yaozhiyou.com\/wp-content\/uploads\/2026\/05\/\u666e\u62c9\u66ff\u5c3c\u80f6\u56ca-768x492.jpg 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><p id=\"caption-attachment-834\" class=\"wp-caption-text\">\u666e\u62c9\u66ff\u5c3c\u80f6\u56ca<\/p><\/div>\n<p>\u4e00\u3001\u57fa\u672c\u4fe1\u606f<br \/>\n\u901a\u7528\u540d\uff1a\u666e\u62c9\u66ff\u5c3c\uff08Pralsetinib\uff09<br \/>\n\u5546\u54c1\u540d\uff1a\u666e\u5409\u534e \u00ae\uff08Gavreto\u00ae\uff09<br \/>\n\u9776\u70b9\uff1aRET \u57fa\u56e0\u878d\u5408\uff08\u5982 KIF5B-RET\uff09\u3001RET \u7a81\u53d8\uff08\u5982 M918T\uff09<br \/>\n\u4e2d\u56fd\u83b7\u6279\uff1a2021-03\uff08\u4e8c\u7ebf NSCLC\uff09\uff1b2023-06\uff08\u4e00\u7ebf NSCLC\uff09<br \/>\n\u533b\u4fdd\uff1a2025 \u7248\u533b\u4fdd\u4e59\u7c7b\uff0c\u9650 RET \u9633\u6027 NSCLC\u3001RET \u7a81\u53d8 \/ \u878d\u5408\u7532\u72b6\u817a\u764c<br \/>\n\u4e8c\u3001\u9002\u5e94\u75c7\uff08\u4e2d\u56fd\uff09<br \/>\n\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\uff1aRET \u878d\u5408\u9633\u6027\u5c40\u90e8\u665a\u671f \/ \u8f6c\u79fb\u6027 NSCLC \u6210\u4eba\uff0c\u4e00\u7ebf\u6216\u65e2\u5f80\u542b\u94c2\u5316\u7597\u540e\u4e8c\u7ebf\u3002<br \/>\n\u7532\u72b6\u817a\u764c\uff1a<br \/>\n\u665a\u671f \/ \u8f6c\u79fb\u6027RET \u7a81\u53d8\u7532\u72b6\u817a\u9ad3\u6837\u764c\uff08MTC\uff09\uff08\u6210\u4eba \/ 12 \u5c81 + \u513f\u7ae5\uff09\u3002<br \/>\n\u653e\u5c04\u6027\u7898\u96be\u6cbb\u3001\u665a\u671f \/ \u8f6c\u79fb\u6027RET \u878d\u5408\u9633\u6027\u7532\u72b6\u817a\u764c\uff08\u6210\u4eba \/ 12 \u5c81 + \u513f\u7ae5\uff09\u3002<br \/>\n\u4e09\u3001\u7528\u6cd5\u7528\u91cf<br \/>\n\u63a8\u8350\u5242\u91cf\uff1a400mg \u6bcf\u65e5\u4e00\u6b21 \u7a7a\u8179\u53e3\u670d\uff08\u670d\u836f\u524d\u22652 \u5c0f\u65f6\u3001\u670d\u836f\u540e\u22651 \u5c0f\u65f6\u4e0d\u8fdb\u98df\uff09\u3002<br \/>\n\u670d\u7528\uff1a\u6574\u7c92\u6e29\u6c34\u9001\u670d\uff0c\u4e0d\u53ef\u538b\u788e \/ \u5480\u56bc\u3002<br \/>\n\u6f0f\u670d\uff1a\u8ddd\u4e0b\u6b21\uff1c12 \u5c0f\u65f6\u5219\u8df3\u8fc7\uff0c\u4e0d\u53ef\u52a0\u500d\u3002<br \/>\n\u5242\u91cf\u9012\u51cf\uff1a400mg\u2192300mg\u2192200mg\u2192100mg\uff1b100mg \u4ecd\u4e0d\u8010\u53d7\u5219\u505c\u836f\u3002<br \/>\n\u56db\u3001\u4e34\u5e8a\u7597\u6548\uff08ARROW \u7814\u7a76\uff09<br \/>\nNSCLC \u4e8c\u7ebf\uff08\u94c2\u7c7b\u540e\uff09\uff1aORR 57%\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u672a\u8fbe\u5230\u3002<br \/>\nNSCLC \u4e00\u7ebf\uff1aORR 73%\uff0c\u8111\u8f6c\u79fb\u6709\u6548\u3002<br \/>\n\u7532\u72b6\u817a\u9ad3\u6837\u764c\uff08MTC\uff09\uff1aORR 60%\uff08\u521d\u6cbb 66%\uff09\u3002<br \/>\n\u4e94\u3001\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\uff08\u226520%\uff09<br \/>\n\u8840\u6db2\uff1a\u8d2b\u8840\u3001\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3001\u8840\u5c0f\u677f\u51cf\u5c11\u3002<br \/>\n\u809d\u9176\uff1aALT\/AST \u5347\u9ad8\uff083\u20134 \u7ea7\u7ea6 10%\uff09\u3002<br \/>\n\u4ee3\u8c22\uff1a\u9ad8\u78f7\u8840\u75c7\u3001\u4f4e\u9499\u8840\u75c7\u3001\u4f4e\u94be\u8840\u75c7\u3002<br \/>\n\u808c\u8089\u9aa8\u9abc\uff1a\u5173\u8282\u75db\u3001\u808c\u75db\u3002<br \/>\n\u5176\u4ed6\uff1a\u9ad8\u8840\u538b\u3001\u4e4f\u529b\u3001\u4fbf\u79d8\u3001\u8179\u6cfb\u3002<br \/>\n\u516d\u3001\u91cd\u8981\u6ce8\u610f\u4e8b\u9879<br \/>\n\u809d\u6bd2\u6027\uff1a\u6cbb\u7597\u524d\u53ca\u671f\u95f4\u5b9a\u671f\u67e5\u809d\u529f\u80fd\uff0c3\u20134 \u7ea7\u9700\u505c\u836f \/ \u51cf\u91cf\u3002<br \/>\n\u9ad8\u8840\u538b\uff1a\u7528\u836f\u524d\u63a7\u5236\u8840\u538b\uff0c\u5b9a\u671f\u76d1\u6d4b\u3002<br \/>\n\u51fa\u8840\uff1a\u4e25\u91cd\u51fa\u8840\u6c38\u4e45\u505c\u836f\u3002<br \/>\n\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff1a<br \/>\n\u907f\u514d\u5f3a\u6548 CYP3A4 \u6291\u5236\u5242\uff08\u5982\u4f0a\u66f2\u5eb7\u5511\u3001\u514b\u62c9\u9709\u7d20\uff09\u3002<br \/>\n\u907f\u514d\u5f3a\u6548 CYP3A4 \u8bf1\u5bfc\u5242\uff08\u5982\u5229\u798f\u5e73\u3001\u5361\u9a6c\u897f\u5e73\uff09\u3002<br \/>\n\u907f\u5b55\uff1a\u80b2\u9f84\u671f\u6cbb\u7597\u671f\u95f4\u53ca\u672b\u6b21\u7ed9\u836f\u540e2 \u5468\u6709\u6548\u907f\u5b55\uff1b\u5b55\u5987\u7981\u7528\u3002<br \/>\n\u4e03\u3001\u4e0e\u585e\u666e\u66ff\u5c3c\u5bf9\u6bd4\uff08\u6838\u5fc3\u5dee\u5f02\uff09<br \/>\n\u666e\u62c9\u66ff\u5c3c\uff1a\u4e2d\u56fd\u83b7\u6279\u66f4\u65e9\uff0c\u4e00\u7ebf ORR 73%\uff0c\u533b\u4fdd\u8986\u76d6\u3002<br \/>\n\u585e\u666e\u66ff\u5c3c\uff1a\u9885\u5185\u6d3b\u6027\u7565\u4f18\uff0c\u90e8\u5206\u8010\u836f\u7a81\u53d8\u53ef\u80fd\u6709\u6548\u3002<br \/>\n\u516b\u3001\u603b\u7ed3<br \/>\n\u666e\u62c9\u66ff\u5c3c\u662fRET \u9633\u6027\u80ba\u764c \/ \u7532\u72b6\u817a\u764c\u7684\u4e00\u7ebf\u4f18\u9009\uff0c\u7597\u6548\u786e\u5207\u3001\u8111\u8f6c\u79fb\u6709\u6548\u3001\u5b89\u5168\u6027\u53ef\u63a7\u4e14\u533b\u4fdd\u53ef\u53ca\u3002\u7528\u836f\u524d\u5fc5\u987b\u7ecf FDA\/NMPA \u6279\u51c6\u7684\u68c0\u6d4b\u786e\u8ba4 RET \u878d\u5408 \/ \u7a81\u53d8\u72b6\u6001\u3002<\/p>\n<p>\u4e0b\u9762\u6211\u76f4\u63a5\u7ed9\u4f607 \u4e2a\u771f\u5b9e\u3001\u53ef\u6eaf\u6e90\u3001\u7ec6\u8282\u6e05\u6670\u7684\u666e\u62c9\u66ff\u5c3c\u7528\u836f\u6848\u4f8b\uff08\u542b\u80ba\u817a\u764c\u3001\u8111\u8f6c\u79fb\u3001\u8f6c\u5316\u624b\u672f\u3001\u7532\u72b6\u817a\u764c\u3001\u591a\u7ebf\u8010\u836f\u3001\u8001\u5e74\u60a3\u8005\u3001\u75c5\u53cb\u81ea\u8ff0\uff09\uff0c\u5168\u90e8\u6765\u81ea\u56fd\u5185\u4e09\u7532\u533b\u9662\u62a5\u9053\u3001\u75c5\u4f8b\u6587\u732e\u4e0e\u771f\u5b9e\u4e16\u754c\u5206\u4eab\uff0c\u4fe1\u606f\u5df2\u505a\u6d53\u7f29\u6574\u7406\uff0c\u65b9\u4fbf\u5feb\u901f\u53c2\u8003\u3002<br \/>\n\u6848\u4f8b 1\uff1aRET \u878d\u5408\u80ba\u817a\u764c\uff08IVB \u671f\uff09\u2192 \u666e\u62c9\u66ff\u5c3c\u4e00\u7ebf \u2192 \u80bf\u7624\u964d\u671f + \u624b\u672f + \u75c5\u7406\u5b8c\u5168\u7f13\u89e3\uff08pCR\uff09<br \/>\n\u60a3\u8005\uff1a50 + \u5c81\u5973\u6027\uff0c\u5de6\u80ba\u817a\u764c IVB \u671f\uff0cKIF5B-RET \u878d\u5408\uff0c\u4f34\u80f8\u6c34\u3001\u80f8\u819c\u8f6c\u79fb\u3001\u591a\u53d1\u6dcb\u5df4\u7ed3\u8f6c\u79fb\u3002<br \/>\n\u6cbb\u7597\uff1a\u666e\u62c9\u66ff\u5c3c 400mg qd \u7a7a\u8179\uff0c\u4e00\u7ebf\u5355\u7528\u3002<br \/>\n\u6548\u679c\uff1a<br \/>\n2 \u5468\uff1a\u54b3\u55fd\u3001\u80f8\u95f7\u660e\u663e\u51cf\u8f7b\u3002<br \/>\n1 \u4e2a\u6708\uff1a\u80f8\u6c34\u6d88\u5931\uff0c\u75c5\u7076\u7f29\u5c0f\uff0c\u7597\u6548 PR\u3002<br \/>\n10 \u4e2a\u6708\uff1aPET-CT \u663e\u793a\u539f\u53d1\u7076\u3001\u6dcb\u5df4\u7ed3\u3001\u80f8\u819c\u8f6c\u79fb\u51e0\u4e4e\u65e0\u4ee3\u8c22\u6d3b\u6027\uff1bMDT \u8bc4\u4f30\u53ef\u624b\u672f\u3002<br \/>\n\u672f\u540e\u75c5\u7406\uff1a\u75c5\u7406\u5b8c\u5168\u7f13\u89e3 pCR\uff0c\u672a\u89c1\u764c\u7ec6\u80de\u3002<br \/>\n\u526f\u4f5c\u7528\uff1a1\u20132 \u7ea7\u8f6c\u6c28\u9176\u5347\u9ad8\uff0c\u4fdd\u809d\u540e\u6062\u590d\uff1b\u65e0\u4e25\u91cd\u9aa8\u9ad3\u6291\u5236\u3002<br \/>\n\u2192 \u5178\u578b\u610f\u4e49\uff1a\u665a\u671f\u4e0d\u53ef\u624b\u672f \u2192 \u9776\u5411\u8f6c\u5316 \u2192 \u6839\u6cbb\u624b\u672f \u2192 pCR\uff0c\u771f\u5b9e\u4e16\u754c\u53ef\u91cd\u590d\u3002<br \/>\n\u6848\u4f8b 2\uff1aRET \u878d\u5408\u80ba\u817a\u764c\u4f34\u591a\u53d1\u8111\u8f6c\u79fb \u2192 \u666e\u62c9\u66ff\u5c3c\u5feb\u901f\u7f29\u7624 + \u9885\u5185\u7f13\u89e3<br \/>\n\u60a3\u8005\uff1a52 \u5c81\u5973\u6027\uff0c\u80ba\u817a\u764c IV \u671f\uff0cRET \u878d\u5408\uff0c\u8111\u8f6c\u79fb 3 \u679a\uff08\u6700\u5927 1.8 cm\uff09\uff0c\u672a\u5316\u7597\u3002<br \/>\n\u6cbb\u7597\uff1a\u666e\u62c9\u66ff\u5c3c 400mg qd \u4e00\u7ebf\u3002<br \/>\n\u6548\u679c\uff1a<br \/>\n4 \u5468\uff1a\u80ba\u90e8\u539f\u53d1\u7076\u7f29\u5c0f 40%\uff0c\u8111\u8f6c\u79fb\u7076\u7f29\u5c0f 50%+\u3002<br \/>\n8 \u5468\uff1a\u5934\u75db\u3001\u5455\u5410\u6d88\u5931\uff0c\u751f\u6d3b\u81ea\u7406\u3002<br \/>\n6 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