{"id":575,"date":"2023-11-01T09:41:22","date_gmt":"2023-11-01T01:41:22","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=575"},"modified":"2023-11-01T10:11:44","modified_gmt":"2023-11-01T02:11:44","slug":"%e6%9b%b2%e7%be%8e%e6%9b%bf%e5%b0%bc-trametinib-%e4%b8%b4%e5%ba%8a%e5%ba%94%e7%94%a8%e8%a6%81%e7%82%b9","status":"publish","type":"post","link":"https:\/\/yaozhiyou.com\/?p=575","title":{"rendered":"\u66f2\u7f8e\u66ff\u5c3c Trametinib \u4e34\u5e8a\u5e94\u7528\u8981\u70b9"},"content":{"rendered":"<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-581 \" src=\"http:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/11\/\u5fae\u4fe1\u56fe\u7247_20231101100645.png\" alt=\"\u66f2\u7f8e\u66ff\u5c3c Trametinib \u4e34\u5e8a\u5e94\u7528\u8981\u70b9\" width=\"558\" height=\"364\" srcset=\"https:\/\/yaozhiyou.com\/wp-content\/uploads\/2023\/11\/\u5fae\u4fe1\u56fe\u7247_20231101100645.png 791w, https:\/\/yaozhiyou.com\/wp-content\/uploads\/2023\/11\/\u5fae\u4fe1\u56fe\u7247_20231101100645-768x501.png 768w\" sizes=\"auto, (max-width: 558px) 100vw, 558px\" \/>\u66f2\u7f8e\u66ff\u5c3c Trametinib<\/strong><\/p>\n<p><strong>\u5236\u5242\u4e0e\u89c4\u683c\uff1a<\/strong>\u7247\u5242\uff1a0.5mg\u30011mg\u30012mg<\/p>\n<p><strong>\u9002\u5e94\u8bc1\uff1a<\/strong><\/p>\n<p><strong>1.<\/strong>\u66f2\u7f8e\u66ff\u5c3c\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u9002\u7528\u4e8e\u6cbb\u7597BRAF V600E\/K\u7a81\u53d8\u9633\u6027\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027<strong>Trametinib<\/strong>\u60a3\u8005\u3002<\/p>\n<p><strong>2.<\/strong>\u66f2\u7f8e\u66ff\u5c3c\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u9002\u7528\u4e8eBRAF 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V600E\/K\u7a81\u53d8\u9633\u6027\u7684\u60a3\u8005\u65b9\u53ef\u63a5\u53d7\u672c\u54c1\u6cbb\u7597\u3002\u672c\u54c1\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u4e0d\u9002\u7528\u4e8eBRAF\u91ce\u751f\u578b\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u3002<\/p>\n<p><strong>2.<\/strong>\u66f2\u7f8e\u66ff\u5c3c\u7684\u63a8\u8350\u5242\u91cf\u662f<strong>2mg\/\u6b21\uff0c\u6bcf\u5929\u4e00\u6b21<\/strong>\uff0c\u53e3\u670d\uff0c\u9700\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u6cbb\u7597\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002\u9996\u6b21\u5242\u91cf\u51cf\u5c11\uff0c1.5mg\/\u6b21\uff0c\u6bcf\u5929\u4e00\u6b21\uff1b\u7b2c2\u6b21\u51cf\u91cf\uff0c1mg\/\u6b21\uff0c\u6bcf\u5929\u4e00\u6b21\uff1b\u5982\u679c\u4e0d\u80fd\u8010\u53d71mg\/\u6b21\uff0c\u6bcf\u5929\u4e00\u6b21\uff0c\u5e94\u6c38\u4e45\u505c\u7528\u3002<\/p>\n<p><strong>3.<\/strong>\u66f2\u7f8e\u66ff\u5c3c\u5e94\u5728<strong>\u9910\u524d\u81f3\u5c111\u5c0f\u65f6\u524d\u6216\u9910\u540e\u81f3\u5c112\u5c0f\u65f6\u540e\u670d\u7528<\/strong>\u3002\u5e94\u5728\u6bcf\u5929\u76f8\u540c\u65f6\u95f4\u670d\u7528\u66f2\u7f8e\u66ff\u5c3c\u3002\u5982\u679c\u9519\u8fc7\u4e00\u5242\u672c\u54c1\uff0c\u987b\u6700\u665a\u5728\u9884\u5b9a\u7684\u4e0b\u4e00\u6b21\u7ed9\u836f\u4e4b\u524d12\u5c0f\u65f6\u8865\u4e0a\u3002\u5982\u679c\u8ddd\u79bb\u4e0b\u6b21\u9884\u5b9a\u7684\u7ed9\u836f\u65f6\u95f4\u77ed\u4e8e12\u5c0f\u65f6\uff0c\u5219\u4e0d\u5e94\u8be5\u8865\u670d\u3002\u672c\u54c1\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u65f6\uff0c\u5e94\u5728\u6bcf\u5929\u76f8\u540c\u65f6\u95f4\u670d\u7528\u672c\u54c1\u6bcf\u5929\u4e00\u6b21\uff0c\u4e0e\u5728\u65e9\u6668\u6216\u665a\u4e0a\u7ed9\u836f\u7684\u8fbe\u62c9\u975e\u5c3c\u4e00\u8d77\u670d\u7528\u3002\u4e0d\u5e94\u5480\u56bc\u6216\u538b\u788e\u672c\u54c1\u3002<\/p>\n<p><strong>4.<\/strong>\u5728\u7ed9\u4e88\u66f2\u7f8e\u66ff\u5c3c\u8054\u5408\u5e94\u7528\u8fbe\u62c9\u975e\u5c3c\u6cbb\u7597\u65f6\uff0c\u5e38\u89c1\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\uff1a<strong>\u53d1\u70ed\u3001\u5bd2\u6218\u3001\u76ae\u75b9\u3001\u5934\u75db\u3001\u5934\u6655\u3001\u5173\u8282\u75db\u3001\u54b3\u55fd<\/strong>\u7b49\u3002\u5982\u679c\u51fa\u73b0\u6cbb\u7597\u76f8\u5173\u7684\u6bd2\u6027\uff0c\u5219\u4e24\u79cd\u6cbb\u7597\u5e94\u540c\u65f6\u8fdb\u884c\u5242\u91cf\u51cf\u5c11\u3001\u4e2d\u65ad\u6216\u505c\u6b62\u3002\u5bf9\u4e8e<strong>\u4e3b\u8981\u4e0e\u66f2\u7f8e\u66ff\u5c3c\u76f8\u5173\u7684\u4e0d\u826f\u53cd\u5e94\uff08\u89c6\u7f51\u819c\u9759\u8109\u963b\u585e\u3001\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\u8131\u79bb\u3001\u95f4\u8d28\u6027\u80ba\u708e\u548c\u5355\u7eaf\u6027\u9759\u8109\u8840\u6813\u6813\u585e\uff09<\/strong>\uff0c\u4ec5\u9700\u5bf9\u66f2\u7f8e\u66ff\u5c3c\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002<\/p>\n<p><strong>5.<\/strong>\u8f7b\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u8f7b\u4e2d\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\u65e0\u9700\u8fdb\u884c\u5242\u91cf\u8c03\u6574\u3002\u4e2d\u91cd\u5ea6\u809d\u529f\u80fd\u635f\u4f24\u60a3\u8005\u3001\u91cd\u5ea6\u80be\u529f\u80fd\u635f\u4f24\u60a3\u8005\uff0c\u5e94\u614e\u7528\u66f2\u7f8e\u66ff\u5c3c\u3002\u8001\u5e74\u60a3\u8005\uff08\u226565\u5c81\uff09\u65e0\u9700\u8c03\u6574\u521d\u59cb\u5242\u91cf\u3002\u5c1a\u672a\u786e\u5b9a\u66f2\u7f8e\u66ff\u5c3c\u572818\u5c81\u4ee5\u4e0b\u513f\u7ae5\u548c\u9752\u5c11\u5e74\u60a3\u8005\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\u3002<\/p>\n<p><strong>6.<\/strong>\u7ecf\u6c34\u89e3\u9176\u4ee3\u8c22\u7684\u836f\u7269\u53ef\u80fd\u5f71\u54cd\u66f2\u7f8e\u66ff\u5c3c\u66b4\u9732\uff0c\u836f\u7269\u95f4\u76f8\u4e92\u4f5c\u7528\u4e0d\u80fd\u6392\u9664\u3002\u66f2\u7f8e\u66ff\u5c3c\u5e94\u8c28\u614e\u8054\u5408\u4f7f\u7528\u5f3a\u6548P-\u7cd6\u86cb\u767d\u6291\u5236\u5242\u3002<\/p>\n<section><strong><sup>\u203b<\/sup><\/strong><strong>7.<\/strong>\u5728\u7f8e\u56fd\uff0c\u66f2\u7f8e\u66ff\u5c3c\u8054\u5408\u8fbe\u62c9\u975e\u5c3c\u83b7\u6279\u7528\u4e8eBRAF 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