{"id":535,"date":"2023-10-28T12:36:09","date_gmt":"2023-10-28T04:36:09","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=535"},"modified":"2023-10-28T12:36:09","modified_gmt":"2023-10-28T04:36:09","slug":"%e7%b1%b3%e6%89%98%e5%9d%a6-%e5%af%86%e5%a6%a5%e5%9d%a6mitotane-%e8%82%be%e4%b8%8a%e8%85%ba%e7%9a%ae%e8%b4%a8%e7%99%8c%e5%85%8b%e6%98%9f%ef%bc%81","status":"publish","type":"post","link":"https:\/\/yaozhiyou.com\/?p=535","title":{"rendered":"\u7c73\u6258\u5766\/\u5bc6\u59a5\u5766(Mitotane)\u2014\u2014\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u514b\u661f\uff01"},"content":{"rendered":"

\"\u7c73\u6258\u5766\/\u5bc6\u59a5\u5766(Mitotane)\u2014\u2014\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u514b\u661f\"<\/p>\n

\u540d\u79f0\uff1a<\/strong>Mitotane\u7c73\u6258\u5766<\/section>\n
\u522b\u540d\uff1a<\/strong>\u6c2f\u82ef\u4e8c\u6c2f\u4e59\u70f7\u3001\u66fc\u6258\u5766\u3001\u89e3\u817a\u7624\u3001Chloditan\u3001Chlonlithane\u3002<\/section>\n
\u5546\u54c1\u540d\uff1a<\/strong>LYSODREN<\/section>\n
\u751f\u4ea7\u5546\uff1a<\/strong>BIGBEAR<\/section>\n
\u89c4\u683c\uff1a<\/strong>500mg*100\u7c92\/\u76d2<\/section>\n
\u4e2d\u56fd\u4e0a\u5e02\u60c5\u51b5\uff1a<\/strong>\u672a\u5728\u4e2d\u56fd\u4e0a\u5e02<\/section>\n
\u57fa\u672c\u4fe1\u606f\uff1a<\/strong>\u672c\u54c1\u7ed3\u6784\u4e0e\u6740\u866b\u836fDDT\u548cDDD\u76f8\u4f3c\uff0c\u53ef\u4f7f\u80be\u4e0a\u817a\u76ae\u8d28\u840e\u7f29\u548c\u574f\u6b7b\u3002\u7ed9\u4e88\u672c\u54c1\u540e\u53ef\u4f7f\u4f53\u5185\u80be\u4e0a\u817a\u76ae\u8d28\u6fc0\u7d20\u53ca\u5176\u4ee3\u8c22\u4ea7\u7269\u6c34\u5e73\u8fc5\u901f\u4e0b\u964d\uff0c\u53ef\u7528\u4e8e\u80be\u4e0a\u817a\u7624\u6216\u80be\u4e0a\u817a\u589e\u751f\u5f15\u8d77\u7684\u67af\u6c0f\u7efc\u5408\u5f81\u3002\u53e3\u670d\u7ea640%\u7531\u80c3\u80a0\u9053\u5438\u6536\uff0c\u5176\u4f5960%\u4ee5\u539f\u578b\u968f\u7caa\u4fbf\u6392\u51fa\u3002\u6bcf\u65e55\uff5e10g\uff0c\u8840\u836f\u6d53\u5ea6\u53ef\u8fbe10\uff5e90\u03bcg\/ml\uff0c\u4ee3\u8c22\u7269\u6d53\u5ea630\uff5e50\u3002\u505c\u836f6\uff5e9\u03bcg\/ml\u5468\u540e\uff0c\u8840\u6d46\u4e2d\u4ecd\u53ef\u6d4b\u5230\u90bb\u6c2f\u70f7\u3002\u672c\u54c1\u8102\u6eb6\u6027\u9ad8\uff0c\u4e3b\u8981\u50a8\u5b58\u4e8e\u8102\u80aa\u4e2d\u3002\u4ece\u5c3f\u4e2d\u6392\u51fa\u7684\u6c34\u6eb6\u6027\u4ee3\u8c22\u7269\u7ea6\u5360\u7ed9\u836f\u91cf\u768425%\u3002<\/section>\n
\u9002\u5e94\u75c7\uff1a<\/strong>\u7c73\u6258\u5766\/\u5bc6\u59a5\u5766\u9002\u7528\u4e8e\u65e0\u6cd5\u624b\u672f\u7684\u3001\u529f\u80fd\u6027\u548c\u975e\u529f\u80fd\u6027\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u3001\u80be\u4e0a\u817a\u76ae\u8d28\u589e\u751f\u4ee5\u53ca\u80bf\u7624\u6240\u81f4\u7684\u76ae\u8d28\u9187\u589e\u591a\u75c7\u3002<\/section>\n
\n
\u7c73\u6258\u5766\u8f85\u52a9\u6cbb\u7597\u2014\u2014\u964d\u4f4e\u590d\u53d1\u98ce\u9669<\/strong><\/section>\n
\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u7684\u590d\u53d1\u98ce\u9669\u9ad8\uff0c\u624b\u672f\u5207\u9664\u540e5\u5e74\u590d\u53d1\u7387\u9ad8\u8fbe75%\uff0c\u7ecf\u4e34\u5e8a\u7814\u7a76\u8868\u660e\uff0c\u624b\u672f\u540e\u4e88\u4ee5\u836f\u7269\u8f85\u52a9\u6cbb\u7597\u80fd\u6709\u6548\u964d\u4f4e\u590d\u53d1\u7387\u3002<\/section>\n
\u6709\u4e00\u9879\u56de\u987e\u6027\u5206\u6790\uff0c\u7eb3\u5165\u4e86177\u540d\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u60a3\u8005\uff0c\u5176\u4e2d47\u540d\u60a3\u8005\u5728\u6839\u6cbb\u672f\u540e\u8f85\u52a9\u4e86\u7c73\u6258\u5766\u6cbb\u7597\uff0c55\u540d\u610f\u5927\u5229\u60a3\u8005(\u5bf9\u7167\u7ec41)\u4e0e75\u540d\u5fb7\u56fd\u60a3\u8005(\u5bf9\u7167\u7ec42)\u672a\u63a5\u53d7\u8f85\u52a9\u6cbb\u7597\uff0c\u5206\u6790\u7ed3\u679c\u8868\u660e\uff0c\u7c73\u6258\u5766\u7ec4\u7684\u4e2d\u4f4d\u65e0\u590d\u53d1\u751f\u5b58\u671f\u4e3a42\u4e2a\u6708\uff0c\u663e\u8457\u957f\u4e8e\u5bf9\u7167\u7ec41\u768410\u4e2a\u6708\uff0c\u4e0e\u5bf9\u7167\u7ec42\u768425\u4e2a\u6708\uff0c\u7c73\u6258\u5766\u6cbb\u7597\u5728\u65e0\u590d\u53d1\u751f\u5b58\u7387\u65b9\u9762\u5177\u6709\u663e\u7740\u4f18\u52bf\uff0c\u4e14\u4e0e\u7c73\u6258\u5766\u76f8\u5173\u7684\u4e0d\u826f\u4e8b\u4ef6\u4e3b\u8981\u662f1\u7ea7\u62162\u7ea7\uff0c\u5c5e\u4e8e\u4e34\u5e8a\u53ef\u63a7\u5236\u8303\u56f4\u3002<\/section>\n
\u53e6\u5916\uff0c\u8fd8\u6709\u7814\u7a76\u8868\u660e\uff0c\u8f85\u52a9\u653e\u7597\u4e5f\u663e\u793a\u51fa\u4e86\u9884\u9632\u5c40\u90e8\u590d\u53d1\u7684\u76ca\u5904\uff0c\u4f46\u6ca1\u6709\u8bc1\u636e\u8868\u660e\u653e\u7597\u5728\u603b\u751f\u5b58\u671f\u4e0a\u6709\u4f18\u52bf\uff0c\u76ee\u524d\uff0c\u4ec5\u5728\u5c40\u90e8\u590d\u53d1\u98ce\u9669\u7279\u522b\u9ad8(R1\u5207\u9664)\u7684\u60c5\u51b5\u4e0b\u624d\u5efa\u8bae\u8f85\u52a9\u653e\u7597\u3002<\/section>\n
\u7c73\u6258\u5766\u8054\u5408\u5316\u7597\u2014\u2014\u8f6c\u79fb\u6027\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u7684\u4e00\u7ebf\u9009\u62e9<\/strong><\/section>\n
\u4e00\u9879\u540d\u4e3aFIRM-ACT\u4e34\u5e8a\u8bd5\u9a8c\u5bf9\u6bd4\u4e86\u7c73\u6258\u5766\u8054\u5408\u4f9d\u6258\u6cca\u82f7-\u987a\u94c2-\u591a\u67d4\u6bd4\u661f(M-EDP)\u4e0e\u7c73\u6258\u5766\u8054\u5408\u94fe\u8132\u4f50\u83cc\u7d20(M-Sz)\u4f5c\u4e3a\u4e00\u7ebf\u6216\u4e8c\u7ebf\u6cbb\u7597\u5c40\u90e8\u665a\u671f\u548c\u8f6c\u79fb\u6027\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u7684\u6548\u679c\uff0c\u8be5\u7814\u7a76\u7eb3\u5165\u4e86304\u540d\u8f6c\u79fb\u6027\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u60a3\u8005\uff0c\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5728\u4e00\u7ebf\u6cbb\u7597\u4e2d\uff0c\u867d\u7136\u5728\u603b\u751f\u5b58\u671f\u4e0a\u4e24\u7ec4\u672a\u89c1\u660e\u663e\u5dee\u5f02\uff0c\u4f46M-EDP\u7ec4\u7684\u7f13\u89e3\u7387\u4e0e\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u90fd\u663e\u8457\u4f18\u4e8eM-Sz\u7ec4\uff0c\u5728\u63a5\u53d7\u66ff\u4ee3\u65b9\u6848\u4f5c\u4e3a\u4e8c\u7ebf\u6cbb\u7597\u7684185\u540d\u60a3\u8005\u4e2d\uff0cM-EDP\u7ec4\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\u4e3a5.6\u4e2a\u6708\u4f18\u4e8eM-Sz\u7ec4\u76842.2\u4e2a\u6708\u3002\u672a\u63a5\u53d7\u66ff\u4ee3\u4e8c\u7ebf\u6cbb\u7597\u7684\u60a3\u8005\u63a5\u53d7\u4e00\u7ebfM-EDP\u6cbb\u7597\u7684\u603b\u751f\u5b58\u671f\u4e3a17.1\u4e2a\u6708\u4f18\u4e8eM-Sz\u7ec4\u76844.7\u4e2a\u6708\u3002<\/section>\n
\u57fa\u4e8e\u4ee5\u4e0a\u7814\u7a76\u6570\u636e\uff0c\u7c73\u6258\u5766\u8054\u5408\u4f9d\u6258\u6cca\u82f7-\u987a\u94c2-\u591a\u67d4\u6bd4\u661f\u88ab\u9009\u4e3a\u8f6c\u79fb\u6027\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u7684\u4e00\u7ebf\u9009\u62e9\u3002\u53e6\u4e5f\u6709\u4e34\u5e8a\u7814\u7a76\u8868\u660e\u5bf9\u4e8eM-EDP\u6cbb\u7597\u5931\u8d25\u7684\u60a3\u8005\uff0c\u5c06\u5409\u897f\u4ed6\u6ee8\u8054\u5408\u5361\u57f9\u4ed6\u6ee8\u4f5c\u4e3a\u4e8c\u7ebf\u5316\u7597\uff0c\u4e5f\u80fd\u4f7f\u60a3\u8005\u751f\u5b58\u83b7\u76ca\u3002<\/section>\n
\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u60a3\u8005\u53ef\u4ee5\u901a\u8fc7\u624b\u672f\u5b8c\u5168\u5207\u9664\u5f97\u5230\u6839\u6cbb\uff0c\u4f46\u590d\u53d1\u7387\u9ad8\uff0c\u53ef\u4ee5\u8f85\u52a9\u836f\u7269\u6cbb\u7597\uff0c\u7c73\u6258\u5766\u3001\u5316\u7597\u3001\u653e\u7597\u4e5f\u5df2\u88ab\u8bc1\u5b9e\u80fd\u4f7f\u80be\u4e0a\u817a\u76ae\u8d28\u764c\u60a3\u8005\u751f\u5b58\u83b7\u76ca\u3002<\/section>\n
\u7528\u6cd5\u7528\u91cf\uff1a<\/strong>\u5bf9\u4e8e18\u5c81\u4ee5\u4e0b\u7684\u513f\u7ae5\uff0c\u6b64\u836f\u7684\u7597\u6548\u53ca\u5b89\u5168\u6027\u5c1a\u672a\u5b8c\u5168\u786e\u5b9a\uff0c\u533b\u751f\u4f1a\u89c6\u4e4e\u60a3\u8005\u7684\u4f53\u91cd\u6216\u8eab\u4f53\u8868\u9762\u9762\u79ef\u6765\u51b3\u5b9a\u6bcf\u65e5\u670d\u7528\u7684\u5242\u91cf\u6210\u4eba\u6bcf\u65e5\u5242\u91cf\u4e3a1\u81f36\u514b(\u53ef\u52063\u81f34\u6b21\u670d)\uff0c\u4e4b\u540e\u53ef\u9010\u6b65\u9012\u589e\u81f3\u6bcf\u65e58\u81f310\u514b\u3002\u4e00\u822c\u5efa\u8bae\u6bcf\u65e5\u6700\u9ad8\u5242\u91cf\u4e3a18\u514b\u7528\u836f\u7981\u5fcc\uff1a\u5bf9\u6b64\u836f\u6709\u8fc7\u654f\u53cd\u5e94\u8005\u4e0d\u5b9c\u670d\u7528\u3002<\/section>\n
\u7c73\u6258\u5766\u7528\u836f\u6ce8\u610f\uff1a<\/strong>\u5bf9\u4e8e\u8f7b\u5fae\u81f3\u4e2d\u7b49\u7a0b\u5ea6\u7684\u809d\u810f\u6216\u80be\u810f\u53d7\u635f\u7684\u60a3\u8005\uff0c\u5242\u91cf\u53ef\u80fd\u9700\u8981\u6839\u636e\u836f\u7269\u7684\u8840\u6db2\u6d53\u5ea6\u76f8\u5e94\u4e0b\u8c03\u5bf9\u4e8e\u4e25\u91cd\u7a0b\u5ea6\u7684\u809d\u810f\u6216\u80be\u810f\u53d7\u635f\u7684\u60a3\u8005\u5219\u4e0d\u5efa\u8bae\u670d\u7528\u6b64\u836f\u3002<\/section>\n
\u7c73\u6258\u5766\u5e38\u89c1\u526f\u4f5c\u7528\uff1a<\/strong>\u6291\u5236\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u3001\u7729\u6655\u3001\u55dc\u7761\u3001\u76ae\u80a4\u51fa\u75b9\u3001\u98df\u6b32\u4e0d\u632f\u3001\u6076\u5fc3\u3001\u5455\u5410\u3001\u8179\u6cfb\u7b49\u5176\u4ed6\u526f\u4f5c\u7528\uff1a\u5934\u75db\u3001\u9ad8\u8840\u538b\u3001\u4f53\u4f4d\u6027\u4f4e\u8840\u538b\u3001\u6291\u90c1\u3001\u795e\u5fd7\u4e0d\u6e05\u3001\u808c\u8089\u9707\u98a4\u3001\u51fa\u8840\u6027\u8180\u80f1\u708e\u7b49<\/section>\n
\u7c73\u6258\u5766\u836f\u7269\u76f8\u4e92\u4f5c\u7528\uff1a<\/strong><\/section>\n
1.Spironolactone(\u87ba\u5185\u916f)\u53ef\u964d\u4f4e\u6b64\u836f\u7684\u7597\u6548\uff0c\u6545\u4e0d\u5efa\u8bae\u540c\u65f6\u4f7f\u7528<\/section>\n
2.\u9152\u7cbe\u3001\u7b2c\u4e00\u4ee3\u6297\u7ec4\u7ec7\u80fa\u836f\u7269(sedative antihistamine)\u3001\u9547\u9759\u5b89\u7720\u836f\u3001\u5417\u5561\u7c7b\u6b62\u75db\u836f\u3001\u6297\u766b\u75eb\u75c7\u836f\u7b49\u5177\u6709\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u6291\u5236\u7684\u4f5c\u7528\uff0c\u5408\u5e76\u4f7f\u7528\u53ef\u589e\u52a0\u76f8\u5173\u7684\u526f\u4f5c\u7528\u5982\u55dc\u7761\u3001\u7729\u6655\u7b49<\/section>\n
3.\u6b64\u836f\u53ef\u589e\u52a0\u809d\u810f\u5bf9\u67d0\u4e9b\u836f\u7269(\u5982\u90e8\u5206\u6297\u766b\u75eb\u75c7\u836f\u7269\u3001\u5df4\u6bd4\u59a5\u7c7b\u836f\u7269\u3001Warfarin\u534e\u6cd5\u6797\u7b49)\u7684\u4ee3\u8c22\uff0c\u5408\u5e76\u4f7f\u7528\u53ef\u4f7f\u540e\u8005\u7684\u836f\u6548\u4e0b\u964d\uff0c\u6545\u9700\u7279\u522b\u76d1\u5bdf<\/section>\n
4.\u670d\u836f\u8005\u5728\u4f7f\u7528\u5176\u4ed6\u836f\u7269\u524d\u8bf7\u5148\u5fb5\u8be2\u533b\u751f\u6216\u836f\u5242\u5e08\u7684\u610f\u89c1\u75c5\u60a3\u8005\u53ca\u5bb6\u5c5e<\/section>\n
\u7c73\u6258\u5766\u6ce8\u610f\u4e8b\u9879\uff1a<\/strong><\/section>\n
1.\u6b64\u836f\u4e43\u5316\u7597\u836f\u7269\uff0c\u5728\u5904\u7406\u53ca\u5f03\u7f6e\u836f\u7269\u65f6\u987b\u5c0f\u5fc3\u8c28\u614e<\/section>\n
2.\u63a5\u89e6\u836f\u7269\u65f6\u6700\u597d\u914d\u6234\u53ef\u5f03\u7f6e\u7684\u624b\u5957\uff0c\u907f\u514d\u7531\u5b55\u5987\u5904\u7406\u836f<\/section>\n
3.\u9971\u809a\u670d\u7528\u6b64\u836f\u53ef\u589e\u52a0\u5438\u6536<\/section>\n
4.\u6b64\u836f\u53ef\u6291\u5236\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff0c\u5f15\u81f4\u55dc\u7761\u3001\u7729\u6655\u7b49\uff0c\u6545\u5728\u670d\u836f\u671f\u95f4\u5c3d\u91cf\u907f\u514d\u9a7e\u9a76\u6216\u64cd\u4f5c\u673a\u68b0\u7b49\u9700\u8981\u9ad8\u5ea6\u7cbe\u795e\u96c6\u4e2d\u529b\u7684\u6d3b\u52a8<\/section>\n
5.\u670d\u836f\u671f\u95f4\u53ef\u80fd\u51fa\u89c6\u80be\u4e0a\u817a\u76ae\u8d28\u529f\u80fd\u4e0d\u5168(adrenocortical insufficiency)\uff0c\u9700\u8981\u65f6\u533b\u533b\u751f\u4f1a\u4e3a\u4e2a\u522b\u75c5\u4eba\u5904\u65b9\u9002\u5f53\u5242\u91cf\u7684\u76ae\u8d28\u6fc0\u7d20\u4f5c\u8865\u5145<\/section>\n
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