{"id":176,"date":"2023-09-19T20:43:43","date_gmt":"2023-09-19T12:43:43","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=176"},"modified":"2023-10-19T18:44:49","modified_gmt":"2023-10-19T10:44:49","slug":"%e4%be%9d%e7%bb%b4%e8%8e%ab%e5%8f%b8%ef%bc%88everolimus%ef%bc%89","status":"publish","type":"post","link":"https:\/\/yaozhiyou.com\/?p=176","title":{"rendered":"\u4f9d\u7ef4\u83ab\u53f8\uff08Everolimus\uff09"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"424\" height=\"335\" src=\"http:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/09\/\u5fae\u4fe1\u56fe\u7247_20230919204036.jpg\" alt=\"\u4f9d\u7ef4\u83ab\u53f8\uff08Everolimus\uff09\" class=\"wp-image-177\" srcset=\"https:\/\/yaozhiyou.com\/wp-content\/uploads\/2023\/09\/\u5fae\u4fe1\u56fe\u7247_20230919204036.jpg 424w, https:\/\/yaozhiyou.com\/wp-content\/uploads\/2023\/09\/\u5fae\u4fe1\u56fe\u7247_20230919204036-300x237.jpg 300w\" sizes=\"auto, (max-width: 424px) 100vw, 424px\" \/><\/figure>\n\n\n\n<p><strong>\u3010\u836f\u54c1\u5c5e\u6027\u3011&nbsp;<\/strong><\/p>\n\n\n\n<p><strong>mTOR\u6291\u5236\u5242<\/strong><strong>\u4e73\u817a\u764c<\/strong><strong>\u80be\u7ec6\u80de\u764c<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><th><strong>\u3010\u836f\u54c1\u7b80\u4ecb\u3011<\/strong><br><br><\/th><td>\u4f9d\u7ef4\u83ab\u53f8\u662f\u4e00\u79cdmTOR\u7684\u6291\u5236\u5242\uff0cPI3K\/AKT\u901a\u8def\u4e0b\u6e38\u7684\u4e00\u79cd\u4e1d\u6c28\u9178\u82cf\u6c28\u9178\u6fc0\u9176\u3002\u5728\u51e0\u79cd\u4eba\u764c\u75c7\u4e2dmTOR\u5931\u8c03\u63a7\uff0c\u4f9d\u7ef4\u83ab\u53f8\u7ed3\u5408\u81f3\u7ec6\u80de\u5185\u86cb\u767d\uff0cFKBP-12\uff0c\u5bfc\u81f4\u4e00\u79cd\u6291\u5236\u5242\u6027\u590d\u5408\u7269\u5f62\u6210\u548cmTOR\u6fc0\u9176\u6d3b\u6027\u7684\u6291\u5236\u3002\u4f9d\u7ef4\u83ab\u53f8\u51cf\u4f4eS6\u6838\u7cd6\u4f53\u86cb\u767d\u6fc0\u9176(S6K1)\u7684\u6d3b\u6027\u548c\u771f\u6838\u751f\u7269\u5ef6\u4f38\u56e0\u5b504E-\u7ed3\u5408\u86cb\u767d(4E-BP)\uff0cmTOR\u7684\u4e0b\u6e38\u6548\u5e94\u5668\uff0c\u6d89\u53ca\u86cb\u767d\u8d28\u5408\u6210\u3002\u6b64\u5916\uff0c\u4f9d\u7ef4\u83ab\u53f8\u6291\u5236\u7f3a\u6c27-\u53ef\u8bf1\u5bfc\u56e0\u5b50\u7684\u8868\u8fbe(\u5982\uff0cHIF-1)\u548c\u51cf\u4f4e\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50(VEGF)\u7684\u8868\u8fbe\u3002<\/td><\/tr><tr><th><strong>\u3010\u836f\u54c1\u7279\u8272\u3011<\/strong><\/th><td>\u5728\u4f53\u5916\u548c\u6216\u4f53\u5185\u7814\u7a76\u4e2d\u901a\u8fc7\u4f9d\u7ef4\u83ab\u53f8mTOR\u7684\u6291\u5236\u4f5c\u7528\u663e\u793a\u51cf\u4f4e\u7ec6\u80de\u589e\u6b96\uff0c\u6291\u5236\u8840\u7ba1\u751f\u6210\u548c\u8461\u8404\u7cd6\u6444\u53d6\u3002\u4f9d\u7ef4\u83ab\u53f8\u9002\u7528\u4e8e\u7528\u8212\u5c3c\u66ff\u5c3c\u6216\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u5931\u8d25\u540e\u665a\u671f\u80be\u7ec6\u80de\u764c\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>\u3010\u9002\u5e94\u75c7\u3011<\/strong><\/p>\n\n\n\n<p>\u3000\u30001)&nbsp; \u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff0cher2\u9634\u6027\u4e73\u817a\u764c<\/p>\n\n\n\n<p>\u3000\u3000\u4f9d\u7ef4\u83ab\u53f8\u8054\u5408\u4f9d\u897f\u7f8e\u5766\uff0c\u7528\u4e8e\u96cc\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff0cHER2\u9634\u6027\u7684\u7edd\u7ecf\u540e\u5987\u5973\uff0c\u5e76\u4e14\u7528\u6765\u66f2\u5511\u6216\u963f\u90a3\u66f2\u5511\u6cbb\u7597\u5931\u8d25\u540e\u7684\u4e73\u817a\u764c\u60a3\u8005\u3002<\/p>\n\n\n\n<p>\u3000\u30002)&nbsp; \u795e\u7ecf\u5185\u5206\u6ccc\u7624<\/p>\n\n\n\n<p>\u3000\u3000\u4f9d\u7ef4\u83ab\u53f8\u9002\u7528\u4e8e\u6210\u4eba\u60a3\u8005\uff0c\u6cbb\u7597\u8fdb\u5c55\uff0c\u5206\u5316\u826f\u597d\uff0c\u975e\u529f\u80fd\u6027\u7684\u80c3\u80a0\u9053(GI)\u6216\u80ba\u90e8\u8d77\u6e90\u7684\uff0c\u4e0d\u53ef\u5207\u9664\u3001\u5c40\u90e8\u8fdb\u5c55\u6216\u8f6c\u79fb\u6027\u795e\u7ecf\u5185\u5206\u6ccc\u7624\uff0c\u3002<\/p>\n\n\n\n<p>\u3000\u30003)&nbsp; \u8212\u5c3c\u66ff\u5c3c\u3001\u7d22\u62c9\u975e\u5c3c\u6cbb\u7597\u5931\u8d25\u540e\u7684\u80be\u7ec6\u80de\u764c<\/p>\n\n\n\n<p>\u3000\u30004\uff09\u7ed3\u8282\u6027\u786c\u5316\u75c7(TSC)\u76f8\u5173\u80be\u8840\u7ba1\u5e73\u6ed1\u808c\u8102\u80aa\u7624<\/p>\n\n\n\n<p>\u3000\u3000\u4f9d\u7ef4\u83ab\u53f8\u9002\u7528\u4e8e\u6210\u4eba\u60a3\u8005\uff0c\u6cbb\u7597\u4e0d\u9700\u8981\u7acb\u5373\u624b\u672f\u7684\u80be\u8840\u7ba1\u5e73\u6ed1\u808c\u8102\u80aa\u7624\u548cTSC\u3002<\/p>\n\n\n\n<p>\u3000\u30005)&nbsp; \u7ed3\u8282\u6027\u786c\u5316\u75c7\u590d\u5408\u7269(TSC)\u76f8\u5173\u7684\u80be\u8840\u7ba1\u808c\u8102\u80aa\u7624<\/p>\n\n\n\n<p>\u3000\u3000\u4f9d\u7ef4\u83ab\u53f8\u9002\u7528\u4e8e\u6210\u4eba\u548c1\u5c81\u4ee5\u4e0a\u513f\u7ae5\uff0c\u6cbb\u7597\u9700\u8981\u6cbb\u7597\u6027\u5e72\u9884\u4f46\u4e0d\u80fd\u6839\u6cbb\u6027\u5207\u9664\u7684\u7ed3\u8282\u6027\u786c\u5316\u75c7(TSC)\u76f8\u5173\u7684\u5ba4\u7ba1\u819c\u5de8\u7ec6\u80de\u661f\u5f62\u7ec6\u80de\u7624(SEGA)\u3002<\/p>\n\n\n\n<p>\u3000\u30006\uff09\u7ed3\u8282\u6027\u786c\u5316\u75c7\u590d\u5408\u7269(TSC)\u76f8\u5173\u53d1\u4f5c\u6027\u766b\u75eb<\/p>\n\n\n\n<p>\u3000\u3000\u4f9d\u7ef4\u83ab\u53f8\u9002\u7528\u4e8e\u6210\u4eba\u548c2\u5c81\u53ca\u4ee5\u4e0a\u7684\u513f\u7ae5\uff0c\u4f5c\u4e3a\u7ed3\u8282\u6027\u786c\u5316\u75c7\u590d\u5408\u7269(TSC)\u76f8\u5173\u7684\u90e8\u5206\u53d1\u4f5c\u6027\u766b\u75eb\u7684\u8f85\u52a9\u6cbb\u7597\u3002<\/p>\n\n\n\n<p><strong>\u3010\u7528\u6cd5\u7528\u91cf\u3011<\/strong><\/p>\n\n\n\n<p>\u3000\u3000\u63a8\u8350\u5242\u91cf\uff1a<\/p>\n\n\n\n<p>\u3000\u30001)&nbsp; \u6fc0\u7d20\u53d7\u4f53\u9633\u6027\uff0cHER2\u9634\u6027\u4e73\u817a\u764c<\/p>\n\n\n\n<p>\u3000\u3000\u4f9d\u7ef4\u83ab\u53f8\u7684\u63a8\u8350\u5242\u91cf\u4e3a10mg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<\/p>\n\n\n\n<p>\u3000\u30002)&nbsp; \u795e\u7ecf\u5185\u5206\u6ccc\u80bf\u7624(NET)<\/p>\n\n\n\n<p>\u3000\u3000\u4f9d\u7ef4\u83ab\u53f8\u7684\u63a8\u8350\u5242\u91cf\u4e3a10mg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<\/p>\n\n\n\n<p>\u3000\u30003\uff09\u80be\u7ec6\u80de\u764c(RCC)<\/p>\n\n\n\n<p>\u3000\u3000\u4f9d\u7ef4\u83ab\u53f8\u7684\u63a8\u8350\u5242\u91cf\u4e3a10mg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<\/p>\n\n\n\n<p>\u3000\u30004\uff09\u7ed3\u8282\u6027\u786c\u5316\u75c7\u590d\u5408\u7269(TSC)\u76f8\u5173\u7684\u80be\u8840\u7ba1\u808c\u8102\u80aa\u7624<\/p>\n\n\n\n<p>\u3000\u3000\u4f9d\u7ef4\u83ab\u53f8\u7684\u63a8\u8350\u5242\u91cf\u4e3a10mg\uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<\/p>\n\n\n\n<p>\u3000\u30005\uff09\u7ed3\u8282\u6027\u786c\u5316\u75c7\u590d\u5408\u7269(TSC)\u76f8\u5173\u7684\u5ba4\u7ba1\u819c\u7ec6\u80de\u661f\u5f62\u7ec6\u80de\u7624(SEGA)<\/p>\n\n\n\n<p>\u3000\u3000\u4f9d\u7ef4\u83ab\u53f8\u7684\u63a8\u8350\u5242\u91cf\u4e3a4.5 mg\/m2 \uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<\/p>\n\n\n\n<p>\u3000\u30006\uff09\u7ed3\u8282\u6027\u786c\u5316\u75c7\u590d\u5408\u7269(TSC)\u76f8\u5173\u53d1\u4f5c\u6027\u766b\u75eb<\/p>\n\n\n\n<p>\u3000\u3000\u4f9d\u7ef4\u83ab\u53f8\u7684\u63a8\u8350\u5242\u91cf\u4e3a5 mg\/m2 \uff0c\u53e3\u670d\uff0c\u6bcf\u65e5\u4e00\u6b21\uff0c\u76f4\u81f3\u75be\u75c5\u8fdb\u5c55\u6216\u51fa\u73b0\u4e0d\u53ef\u8010\u53d7\u7684\u6bd2\u6027\u3002<\/p>\n\n\n\n<p><strong>\u3010\u4e0d\u826f\u53cd\u5e94\u3011<\/strong><\/p>\n\n\n\n<p>\u3000\u30001\uff09\u611f\u67d3\u6027\u80ba\u708e\u3002<\/p>\n\n\n\n<p>\u3000\u30002\uff09\u53e3\u8154\u708e\u3002<\/p>\n\n\n\n<p>\u3000\u30003)&nbsp; \u4ee3\u8c22\u5f02\u5e38\uff1a\u9ad8\u8840\u7cd6\u6216\u8840\u8102\u5f02\u5e38\u3002<\/p>\n\n\n\n<p>\u3000\u30004\uff09\u8840\u5c0f\u677f\u51cf\u5c11\uff1b\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\uff1b\u53d1\u70ed\u6027\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u3002<\/p>\n\n\n\n<p>\u3000\u30005\uff09\u5176\u4ed6\u975e\u8840\u6db2\u6027\u6bd2\u6027\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h4 class=\"wp-block-heading\">\u514d\u8d23\u58f0\u660e\uff1a\u7531\u672c\u6587\u6240\u8868\u8fbe\u7684\u4efb\u4f55\u5173\u4e8e\u75be\u75c5\u7684\u5efa\u8bae\u90fd\u4e0d\u5e94\u8be5\u88ab\u89c6\u4e3a\u533b\u751f\u7684\u5efa\u8bae\u6216\u66ff\u4ee3\u54c1\uff0c\u8bf7\u54a8\u8be2\u60a8\u7684\u6cbb\u7597\u533b\u751f\u4e86\u89e3\u66f4\u591a\u7ec6\u8282\u3002\u672c\u7ad9\u4fe1\u606f\u4ec5\u4f9b\u53c2\u8003\uff0c\u836f\u76f4\u90ae\u4e0d\u627f\u62c5\u4efb\u4f55\u8d23\u4efb\u3002<\/h4>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u836f\u54c1\u5c5e\u6027\u3011&nbsp; mTOR\u6291\u5236\u5242\u4e73\u817a\u764c\u80be\u7ec6\u80de\u764c \u3010\u836f\u54c1\u7b80\u4ecb\u3011 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\u836f\u4e4b\u53cb<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/yaozhiyou.com\/?p=176\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u4f9d\u7ef4\u83ab\u53f8\uff08Everolimus\uff09 - \u836f\u4e4b\u53cb\" \/>\n<meta property=\"og:description\" content=\"\u3010\u836f\u54c1\u5c5e\u6027\u3011&nbsp; mTOR\u6291\u5236\u5242\u4e73\u817a\u764c\u80be\u7ec6\u80de\u764c \u3010\u836f\u54c1\u7b80\u4ecb\u3011 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