{"id":124,"date":"2023-09-18T20:41:55","date_gmt":"2023-09-18T12:41:55","guid":{"rendered":"http:\/\/www.yaozhiyou.com\/?p=124"},"modified":"2023-09-18T20:41:56","modified_gmt":"2023-09-18T12:41:56","slug":"%e6%b3%a2%e7%94%9f%e5%9d%a6%ef%bc%88bosentan%ef%bc%89","status":"publish","type":"post","link":"https:\/\/yaozhiyou.com\/?p=124","title":{"rendered":"\u6ce2\u751f\u5766\uff08Bosentan\uff09"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"400\" height=\"266\" src=\"http:\/\/www.yaozhiyou.com\/wp-content\/uploads\/2023\/09\/t017a398f3cd378cd69.png\" alt=\"\" class=\"wp-image-125\" srcset=\"https:\/\/yaozhiyou.com\/wp-content\/uploads\/2023\/09\/t017a398f3cd378cd69.png 400w, https:\/\/yaozhiyou.com\/wp-content\/uploads\/2023\/09\/t017a398f3cd378cd69-300x200.png 300w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">\u7528\u836f\u7ba1\u7406<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">\u53e3\u670d\u60ac\u6d6e\u6db2\u5236\u5242<\/h3>\n\n\n\n<p>\u5982\u679c\u9700\u8981\uff0c\u53ef\u4ee5\u901a\u8fc7\u6cbf\u7740\u5207\u5165\u8868\u9762\u7684\u7ebf\u65ad\u88c2\u5c0632mg\u53ef\u5206\u6563\u7247\u5242\u5206\u6210\u4e24\u534a<\/p>\n\n\n\n<p>\u544a\u77e5\u60a3\u8005\u6ce2\u751f\u5766\u5206\u6563\u7247\u4e0d\u5e94\u5206\u6210\u56db\u5206\u4e4b\u4e00<\/p>\n\n\n\n<p>\u6bcf\u79cd32mg\u53ef\u5206\u6563\u7247\u5242\u6216\u7247\u5242\u90e8\u5206\u53ef\u4ee5\u5206\u6563\u5728\u6700\u5c11\u91cf\u7684\u6c34\u4e2d\uff0c\u4ee5\u5728\u7ed9\u836f\u524d\u7acb\u5373\u5236\u6210\u6db2\u4f53\u836f\u7269<\/p>\n\n\n\n<p>\u7247\u5242\u5b8c\u5168\u5206\u6563<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u53e3\u670d\u7ba1\u7406<\/h3>\n\n\n\n<p>\u5e26\u6216\u4e0d\u5e26\u98df\u7269<\/p>\n\n\n\n<p>\u5982\u679c\u9519\u8fc7\u5242\u91cf\uff0c\u8bf7\u5c3d\u5feb\u670d\u7528\u7247\u5242;&nbsp;\u4e0d\u8981\u540c\u65f6\u670d\u75282\u5242;&nbsp;\u5982\u679c\u63a5\u8fd1\u4e0b\u4e00\u6b21\u7ed9\u836f\uff0c\u5219\u8df3\u8fc7\u9519\u8fc7\u7684\u5242\u91cf<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u5b58\u50a8<\/h3>\n\n\n\n<p>\u8584\u819c\u5305\u8863\u548c\u5206\u6563\u7247\uff1a\u572820-25\u00baC\uff0868-77\u00baF\uff09\u4fdd\u5b58<\/p>\n\n\n\n<p>\u5141\u8bb8\u572815-30\u00b0C\uff0859-86\u00b0F\uff09\u4e4b\u95f4\u8fdb\u884c\u77ed\u9014\u65c5\u884c<\/p>\n\n\n\n<p>\u5206\u5f00\u7684\u53ef\u5206\u6563\u7247\u5242\u5e94\u5728\u76f8\u540c\u6761\u4ef6\u4e0b\u50a8\u5b58\uff0c\u5e76\u57287\u5929\u5185\u4f7f\u7528<\/p>\n\n\n\n<p>\u7247\u5242\u788e\u7247\u53ef\u80fd\u4f1a\u8fd4\u56de\u6253\u5f00\u7684\u6c34\u6ce1\uff0c\u5e76\u5b58\u653e\u5728\u513f\u7ae5\u63a5\u89e6\u4e0d\u52307\u5929\u7684\u5730\u65b9<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">\u6210\u4eba<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">\u5242\u578b<\/h3>\n\n\n\n<p>\u7247\u5242 62.5\u6beb\u514b\/125\u6beb\u514b<\/p>\n\n\n\n<p>\u7247\u5242\uff0c\u7528\u4e8e\u53e3\u670d\u6df7\u60ac\u6db2 32\u6beb\u514b<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u80ba\u52a8\u8109\u9ad8\u538b\uff08PAH\uff09<\/h3>\n\n\n\n<p>\u8868\u660e\u53ef\u4ee5\u63d0\u9ad8\u8fd0\u52a8\u80fd\u529b\uff0c\u51cf\u5c11PAH\u7684\u6076\u5316;&nbsp;NYHA II-IV\u663e\u793a\u7684\u6709\u6548\u6027\uff0c\u7279\u53d1\u6027\u6216\u9057\u4f20\u6027PAH\uff0c\u5bfc\u81f4PAH\u7684\u7ed3\u7f14\u7ec4\u7ec7\u75be\u75c5\uff0c\u4ee5\u53ca\u4e0e\u5de6\u5411\u53f3\u5206\u6d41\u7684\u5148\u5929\u6027\u5fc3\u810f\u75c5\u76f8\u5173\u7684PAH<\/p>\n\n\n\n<p>&lt;40 kg\uff1a\u7ef4\u6301\u5242\u91cf\u4e3a62.5 mg \u53e3\u670d 12\u5c0f\u65f6\/1\u6b21<\/p>\n\n\n\n<p>&gt; 40kg\uff1a62.5mg \u53e3\u670d 12\u5c0f\u65f6\/1\u6b21\uff0c\u6301\u7eed4\u5468\uff0c\u7136\u540e\u589e\u52a0\u81f3\u7ef4\u6301\u5242\u91cf125mg \u53e3\u670d 12\u5c0f\u65f6\/1\u6b21<\/p>\n\n\n\n<p>\u505c\u6b62\u6cbb\u7597\uff1a\u8003\u8651\u5c06\u5242\u91cf\u51cf\u5c11\u81f362.5 mg \u53e3\u670d 12\u5c0f\u65f6\/1\u6b21\uff0c\u6301\u7eed3-7\u5929<\/p>\n\n\n\n<p>\u5242\u91cf\u8c03\u6574<\/p>\n\n\n\n<p>ALT \/ AST\u6c34\u5e73\u5347\u9ad8<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5982\u679cALT \/ AST\u6c34\u5e73\u5347\u9ad8\u4f34\u6709\u809d\u6bd2\u6027\u4e34\u5e8a\u75c7\u72b6\uff08\u5982\u6076\u5fc3\uff0c\u5455\u5410\uff0c\u53d1\u70ed\uff0c\u8179\u75db\uff0c\u9ec4\u75b8\uff0c\u5f02\u5e38\u55dc\u7761\uff0c\u75b2\u52b3\uff09\u6216\u80c6\u7ea2\u7d20\u22652XULN\uff0c\u5219\u505c\u836f;&nbsp;\u91cd\u65b0\u5f15\u5165\u7814\u7a76\u5c1a\u672a\u786e\u5b9a<\/li>\n\n\n\n<li>\u5982\u679c\u786e\u8ba4\uff0c\u786e\u8ba4\u6d4b\u8bd5\uff0c\u5982\u4e0b\u6240\u8ff0\u51cf\u5c11\/\u4fdd\u6301\u5242\u91cf<\/li>\n\n\n\n<li>&gt; 12\u5e74&gt; 40 kg\uff1a\u5c06\u5242\u91cf\u51cf\u5c11\u81f362.5 mg \u53e3\u670d 12\u5c0f\u65f6\/1\u6b21\u6216\u4e2d\u65ad\u6cbb\u7597\u5e76\u81f3\u5c11\u76d1\u6d4b\u809d\u810f\u68c0\u67e5q2\u5468; \u5982\u679c\u6c34\u5e73\u6062\u590d\u5230\u6cbb\u7597\u524d\u7684\u503c\uff0c\u7ee7\u7eed\u6216\u91cd\u65b0\u5f15\u5165\u6cbb\u759762.5mg \u53e3\u670d 12\u5c0f\u65f6\/1\u6b21; \u57283\u5929\u5185\u91cd\u65b0\u8bc4\u4f30\u6c34\u5e73<\/li>\n\n\n\n<li>> 5\u4e14<8X ULN\n<ul class=\"wp-block-list\">\n<li>\u4e2d\u65ad\u6cbb\u7597\u548c\u76d1\u6d4bAST \/ ALT\u81f3\u5c11q2\u5468<\/li>\n\n\n\n<li>&gt; 12\u5e74\u4e14&gt; 40 kg\uff1a\u5982\u679c\u6c34\u5e73\u6062\u590d\u5230\u6cbb\u7597\u524d\u7684\u503c\uff0c\u8bf7\u8003\u8651\u5c06\u5242\u91cf\u91cd\u65b0\u5f15\u516562.5 mg \u53e3\u670d 12\u5c0f\u65f6\/1\u6b21; \u57283\u5929\u5185\u91cd\u65b0\u8bc4\u4f30\u6c34\u5e73<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>> 8X ULN\n<ul class=\"wp-block-list\">\n<li>\u505c\u6b62\u6cbb\u7597;&nbsp;\u4e0d\u5e94\u8003\u8651\u91cd\u65b0\u5f15\u5165<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u809d\u529f\u80fd\u635f\u5bb3<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6e29\u548c\uff1a\u65e0\u9700\u8c03\u6574\u5242\u91cf<\/li>\n\n\n\n<li>\u4e2d\u5ea6\u6216\u91cd\u5ea6\uff1a\u907f\u514d\u4f7f\u7528<\/li>\n\n\n\n<li>AST \/ ALT&gt; 3X ULN\uff1a\u907f\u514d\u4f7f\u7528<\/li>\n<\/ul>\n\n\n\n<p>\u4e0e\u5229\u6258\u90a3\u97e6\u5171\u540c\u7ed9\u836f<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5df2\u63a5\u53d7\u5229\u6258\u90a3\u97e6\u81f3\u5c1110\u5929\uff1a\u6839\u636e\u63a8\u8350\u7684\u8d77\u59cb\u5242\u91cf\u6bcf\u5929\u53e3\u670d\u6216\u57fa\u4e8e\u8010\u53d7\u6027\u6bcf\u9694\u4e00\u5929\u5f00\u59cb\u4f7f\u7528\u6ce2\u751f\u5766<\/li>\n\n\n\n<li>\u5df2\u63a5\u53d7\u6ce2\u751f\u5766\uff1a\u5728\u5f00\u59cb\u5229\u6258\u90a3\u97e6\u524d36\u5c0f\u65f6\u505c\u7528\u6ce2\u751f\u5766;&nbsp;\u5728\u63a8\u8350\u7684\u521d\u59cb\u5242\u91cf\u6bcf\u5929\u53e3\u670d\u6216\u5728\u5229\u6258\u90a3\u97e6\u6cbb\u7597\u81f3\u5c1110\u5929\u540e\u6bcf\u9694\u4e00\u5929\u6062\u590d\u6ce2\u751f\u5766<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u7279\u53d1\u6027\u80ba\u7ea4\u7ef4\u5316\uff08\u5b64\u513f\u836f\uff09<\/h3>\n\n\n\n<p>\u7cfb\u7edf\u6027\u786c\u5316\u75c7\uff08\u5b64\u513f\u836f\uff09<\/p>\n\n\n\n<p>\u51cf\u5c11\u7cfb\u7edf\u6027\u786c\u5316\u75c7\u60a3\u8005\u65b0\u6570\u5b57\u6e83\u75a1\u7684\u6570\u91cf\uff08\u6cbb\u7597\uff09<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">\u513f\u79d1<\/h3>\n\n\n\n<h3 class=\"wp-block-heading\">\u5242\u578b<\/h3>\n\n\n\n<p>\u7247\u5242\uff0c\u8584\u819c\u5305\u8863 62.5mg\/125\u6beb\u514b<\/p>\n\n\n\n<p>\u7247\u5242\uff0c\u7528\u4e8e\u53e3\u670d\u6df7\u60ac\u6db2 32\u6beb\u514b<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u80ba\u52a8\u8109\u9ad8\u538b\uff08PAH\uff09<\/h3>\n\n\n\n<p>\u9002\u7528\u4e8e\u7279\u53d1\u6027\u6216\u5148\u5929\u6027PAH\u7684\u22653\u5c81\u513f\u7ae5\u548c\u9752\u5c11\u5e74\uff0c\u4ee5\u6539\u5584\u80ba\u8840\u7ba1\u963b\u529b\uff08PVR\uff09<\/p>\n\n\n\n<p>\u89c1\u7ba1\u7406<\/p>\n\n\n\n<p>&lt;3\u5e74\uff1a\u672a\u5efa\u7acb\u5b89\u5168\u6027\u548c\u6709\u6548\u6027<\/p>\n\n\n\n<p>3\u81f3\u226512\u5e74<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u22654-8kg\uff1a\u7ef4\u6301\u5242\u91cf\u4e3a16 mg \u53e3\u670d 12\u5c0f\u65f6\/1\u6b21<\/li>\n\n\n\n<li>&gt; 8-16\u5343\u514b\uff1a\u7ef4\u6301\u5242\u91cf\u4e3a32\u6beb\u514b\u53e3\u670d 12\u5c0f\u65f6\/1\u6b21<\/li>\n\n\n\n<li>&gt; 16-24 kg\uff1a\u7ef4\u6301\u5242\u91cf\u4e3a48 mg \u53e3\u670d 12\u5c0f\u65f6\/1\u6b21<\/li>\n\n\n\n<li>&gt; 24-40kg\uff1a\u7ef4\u6301\u5242\u91cf\u4e3a64mg \u53e3\u670d 12\u5c0f\u65f6\/1\u6b21<\/li>\n<\/ul>\n\n\n\n<p>&gt; 12\u5e74<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>&lt;40 kg\uff1a\u7ef4\u6301\u5242\u91cf\u4e3a62.5mg \u53e3\u670d 12\u5c0f\u65f6\/1\u6b21<\/li>\n\n\n\n<li>&gt; 40kg\uff1a62.5mg \u53e3\u670d 12\u5c0f\u65f6\/1\u6b21 \u6700\u521d\u6301\u7eed4\u5468\uff0c\u7136\u540e\u589e\u52a0\u81f3\u7ef4\u6301\u5242\u91cf125mg\u53e3\u670d 12\u5c0f\u65f6\/1\u6b21<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u5242\u91cf\u4fee\u6539<\/h3>\n\n\n\n<p>\u5982\u679cALT \/ AST\u6c34\u5e73\u5347\u9ad8\u4f34\u6709\u809d\u6bd2\u6027\u4e34\u5e8a\u75c7\u72b6\uff08\u5982\u6076\u5fc3\uff0c\u5455\u5410\uff0c\u53d1\u70ed\uff0c\u8179\u75db\uff0c\u9ec4\u75b8\uff0c\u5f02\u5e38\u55dc\u7761\uff0c\u75b2\u52b3\uff09\u6216\u80c6\u7ea2\u7d20\u22652XULN\uff0c\u5219\u505c\u836f;&nbsp;\u4e0d\u5e94\u8003\u8651\u91cd\u65b0\u5f15\u5165<\/p>\n\n\n\n<p>ALT \/ AST\u6c34\u5e73\u5347\u9ad8<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u786e\u8ba4\u6d4b\u8bd5\uff0c\u5982\u679c\u786e\u8ba4<\/li>\n\n\n\n<li>> 3\u4e14<5X ULN\n<ul class=\"wp-block-list\">\n<li>&gt; 12\u5e74&gt; 40 kg\uff1a\u5c06\u5242\u91cf\u51cf\u5c11\u81f362.5 mg \u53e3\u670d 12\u5c0f\u65f6\/1\u6b21\u6216\u4e2d\u65ad\u6cbb\u7597\u5e76\u81f3\u5c11\u76d1\u6d4b\u809d\u810f\u68c0\u67e5q2\u5468; \u5982\u679c\u6c34\u5e73\u6062\u590d\u5230\u6cbb\u7597\u524d\u7684\u503c\uff0c\u7ee7\u7eed\u6216\u91cd\u65b0\u5f15\u5165\u6cbb\u759762.5mg \u53e3\u670d 12\u5c0f\u65f6\/1\u6b21; \u57283\u5929\u5185\u91cd\u65b0\u8bc4\u4f30\u6c34\u5e73<\/li>\n\n\n\n<li>\u22653-12\u5c81\u4e14&lt;40 kg\uff1a\u4e2d\u65ad\u6cbb\u7597;&nbsp;\u5982\u679c\u6c34\u5e73\u6062\u590d\u5230\u6cbb\u7597\u524d\u7684\u503c\uff0c\u8003\u8651\u91cd\u65b0\u5f15\u5165\u521d\u59cb\u5242\u91cf;&nbsp;\u57283\u5929\u5185\u91cd\u65b0\u8bc4\u4f30\u6c34\u5e73<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>> 5\u4e14<8X ULN\n<ul class=\"wp-block-list\">\n<li>\u4e2d\u65ad\u6cbb\u7597\u548c\u76d1\u6d4bAST \/ ALT\u81f3\u5c11q2\u5468<\/li>\n\n\n\n<li>&gt; 12\u5e74\u4e14&gt; 40 kg\uff1a\u5982\u679c\u6c34\u5e73\u6062\u590d\u5230\u6cbb\u7597\u524d\u7684\u503c\uff0c\u8bf7\u8003\u8651\u5c06\u5242\u91cf\u91cd\u65b0\u5f15\u516562.5 mg \u53e3\u670d 12\u5c0f\u65f6\/1\u6b21; \u57283\u5929\u5185\u91cd\u65b0\u8bc4\u4f30\u6c34\u5e73<\/li>\n\n\n\n<li>\u22653-12\u5c81\u4e14&lt;40 kg\uff1a\u5982\u679c\u6c34\u5e73\u6062\u590d\u5230\u6cbb\u7597\u524d\u7684\u503c\uff0c\u8bf7\u8003\u8651\u91cd\u65b0\u5f15\u5165\u521d\u59cb\u5242\u91cf;&nbsp;\u57283\u5929\u5185\u91cd\u65b0\u8bc4\u4f30\u6c34\u5e73<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>> 8X ULN\n<ul class=\"wp-block-list\">\n<li>\u505c\u6b62\u6cbb\u7597;&nbsp;\u4e0d\u5e94\u8003\u8651\u91cd\u65b0\u5f15\u5165<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>\u4e0e\u5229\u6258\u90a3\u97e6\u5171\u540c\u7ed9\u836f<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5df2\u63a5\u53d7\u5229\u6258\u90a3\u97e6\u81f3\u5c1110\u5929\uff1a\u6839\u636e\u63a8\u8350\u7684\u8d77\u59cb\u5242\u91cf\u6bcf\u5929\u53e3\u670d\u6216\u57fa\u4e8e\u8010\u53d7\u6027\u6bcf\u9694\u4e00\u5929\u5f00\u59cb\u4f7f\u7528\u6ce2\u751f\u5766<\/li>\n\n\n\n<li>\u63a5\u53d7\u6ce2\u751f\u5766\u6cbb\u7597\uff1a\u5728\u5f00\u59cb\u5229\u6258\u90a3\u97e6\u6cbb\u7597\u524d\u505c\u7528\u6ce2\u751f\u5766&lt;36\u5c0f\u65f6;&nbsp;\u5728\u63a8\u8350\u7684\u521d\u59cb\u5242\u91cf\u6bcf\u5929\u53e3\u670d\u6216\u5728\u5229\u6258\u90a3\u97e6\u6cbb\u7597\u81f3\u5c1110\u5929\u540e\u6bcf\u9694\u4e00\u5929\u6062\u590d\u6ce2\u751f\u5766<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">\u4e0d\u826f\u53cd\u5e94<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">&gt; 10\uff05<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Hgb\u4e0b\u964d;&nbsp;&gt; 1 g \/ dL\uff0857\uff05\uff09<\/li>\n\n\n\n<li>\u547c\u5438\u9053\u611f\u67d3\uff0822\uff05\uff09<\/li>\n\n\n\n<li>\u5934\u75db\uff0816\uff05\uff09<\/li>\n\n\n\n<li>\u6c34\u80bf\uff0811\uff05\uff09<\/li>\n\n\n\n<li>\u9f3b\u54bd\u708e\uff0811\uff05\uff09<\/li>\n\n\n\n<li>\u51b2\u6d17\uff0810\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u8840\u538b\uff0810\uff05\uff09<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">1-10\uff05<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u80f8\u75db\uff085\uff05\uff09<\/li>\n\n\n\n<li>\u6655\u53a5\uff085\uff05\uff09<\/li>\n\n\n\n<li>\u4f4e\u8840\u538b\uff084\uff05\uff09<\/li>\n\n\n\n<li>\u9f3b\u7aa6\u708e\uff084\uff05\uff09<\/li>\n\n\n\n<li>\u5173\u8282\u75db\uff084\uff05\uff09<\/li>\n\n\n\n<li>AST \/ ALT\u5f02\u5e38\uff084\uff05\uff09<\/li>\n\n\n\n<li>\u5fc3\u60b8\uff084\uff05\uff09<\/li>\n\n\n\n<li>\u8d2b\u8840\uff084\uff05\uff09<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u4e0a\u5e02\u540e\u62a5\u544a<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u539f\u56e0\u4e0d\u660e\u7684\u809d\u786c\u5316<\/li>\n\n\n\n<li>\u809d\u529f\u80fd\u8870\u7aed<\/li>\n\n\n\n<li>\u8fc7\u654f\uff0cDRESS\u548c\u8fc7\u654f\u53cd\u5e94<\/li>\n\n\n\n<li>\u8840\u5c0f\u677f\u51cf\u5c11<\/li>\n\n\n\n<li>\u76ae\u75b9<\/li>\n\n\n\n<li>\u9ec4\u75b8<\/li>\n\n\n\n<li>\u8d2b\u8840\u9700\u8981\u8f93\u8840<\/li>\n\n\n\n<li>\u4e2d\u6027\u7c92\u7ec6\u80de\u51cf\u5c11\u75c7\u548c\u767d\u7ec6\u80de\u51cf\u5c11\u75c7<\/li>\n\n\n\n<li>\u9f3b\u585e<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">\u7981\u5fcc<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8fc7\u654f\u75c7<\/li>\n\n\n\n<li>\u6000\u5b55<\/li>\n\n\n\n<li>\u4f34\u968f\u4f7f\u7528\u73af\u5b62\u83cc\u7d20\u6216\u683c\u5217\u672c\u8132<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">\u6ce8\u610f\u4e8b\u9879<\/h3>\n\n\n\n<p>\u6ce2\u751f\u5766\u8d85\u654f\u53cd\u5e94;&nbsp;\u89c2\u5bdf\u5230\u7684\u53cd\u5e94\u5305\u62ec\u836f\u7269\u53cd\u5e94\u4e0e\u55dc\u9178\u6027\u7c92\u7ec6\u80de\u589e\u591a\u75c7\u548c\u7cfb\u7edf\u75c7\u72b6\uff08DRESS\uff09\uff0c\u8fc7\u654f\u53cd\u5e94\uff0c\u76ae\u75b9\u548c\u8840\u7ba1\u6027\u6c34\u80bf<\/p>\n\n\n\n<p>\u76d1\u63a7LFT;&nbsp;\u5982\u679cALT\u6216AST&gt; 3 x ULN\u6216\u80c6\u7ea2\u7d20&gt; 2 x ULN\uff0c\u8bf7\u907f\u514d\u4f7f\u7528\uff08\u53c2\u89c1\u9ed1\u5323\u5b50\u8b66\u544a\u548c\u5242\u91cf\u4fee\u6539\uff09<\/p>\n\n\n\n<p>\u53ef\u80fd\u53d1\u751f\u80ba\u6c34\u80bf;&nbsp;\u5982\u679c\u51fa\u73b0\u4f53\u5f81\/\u75c7\u72b6\uff0c\u53ef\u8003\u8651\u53ef\u80fd\u4e0e\u80ba\u9759\u8109\u95ed\u585e\u6027\u75be\u75c5\u76f8\u5173\uff0c\u4ee5\u53ca\u662f\u5426\u5e94\u505c\u6b62\u6cbb\u7597<\/p>\n\n\n\n<p>\u62a5\u544a\u4e86\u80da\u80ce \u2013 \u80ce\u513f\u6bd2\u6027;&nbsp;\u770b\u9ed1\u5323\u5b50\u8b66\u544a\u548c\u6000\u5b55<\/p>\n\n\n\n<p>\u89c2\u5bdf\u5230\u7cbe\u5b50\u6570\u91cf\u51cf\u5c11;&nbsp;\u4e34\u5e8a\u524d\u6570\u636e\u4e5f\u63d0\u793a\u6ce2\u751f\u5766\u548c\u5176\u4ed6\u5185\u76ae\u7d20\u53d7\u4f53\u62ee\u6297\u5242\u53ef\u80fd\u5bf9\u7cbe\u5b50\u53d1\u751f\u6709\u4e0d\u826f\u5f71\u54cd<\/p>\n\n\n\n<p>\u6cbb\u7597\u53ef\u80fd\u4f1a\u51fa\u73b0\u5242\u91cf\u76f8\u5173\u7684\u8840\u7ea2\u86cb\u767d\u548c\u8840\u7ec6\u80de\u6bd4\u5bb9\u964d\u4f4e;&nbsp;\u5efa\u8bae\u57281\u4e2a\u6708\uff0c3\u4e2a\u6708\u540e\u548c3\u4e2a\u6708\u540e\u68c0\u67e5\u8840\u7ea2\u86cb\u767d\u6d53\u5ea6;&nbsp;\u5982\u679c\u8840\u7ea2\u86cb\u767d\u6d53\u5ea6\u663e\u7740\u964d\u4f4e\uff0c\u5e94\u8fdb\u4e00\u6b65\u8bc4\u4f30\u4ee5\u786e\u5b9a\u7279\u5b9a\u6cbb\u7597\u7684\u539f\u56e0\u548c\u9700\u8981<\/p>\n\n\n\n<p>\u6db2\u4f53\u4fdd\u7559<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5916\u5468\u6027\u6c34\u80bf\u662fPAH\u7684\u5df2\u77e5\u4e34\u5e8a\u540e\u679c\uff0cPAH\u6076\u5316\uff0c\u4e5f\u662f\u6ce2\u751f\u5766\u548c\u5176\u4ed6\u5185\u76ae\u7d20\u53d7\u4f53\u62ee\u6297\u5242\u7684\u5df2\u77e5\u4f5c\u7528\u3002<\/li>\n\n\n\n<li>\u5728\u6ce2\u751f\u5766\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u62a5\u9053\u4e86\u6db2\u4f53\u6f74\u7559\u6216\u6c34\u80bf\u7684\u7efc\u5408\u4e0d\u826f\u4e8b\u4ef6<\/li>\n\n\n\n<li>\u60a3\u8005\u9700\u8981\u901a\u8fc7\u5229\u5c3f\u5242\uff0c\u6db2\u4f53\u7ba1\u7406\u6216\u4f4f\u9662\u6cbb\u7597\u6765\u6cbb\u7597\u5931\u8d25\u7684\u5fc3\u529b\u8870\u7aed<\/li>\n\n\n\n<li>\u5982\u679c\u51fa\u73b0\u4e34\u5e8a\u4e0a\u663e\u7740\u7684\u6db2\u4f53\u6f74\u7559\uff0c\u65e0\u8bba\u662f\u5426\u6709\u76f8\u5173\u7684\u4f53\u91cd\u589e\u52a0\uff0c\u5e94\u8fdb\u4e00\u6b65\u8bc4\u4f30\u4ee5\u786e\u5b9a\u6cbb\u7597\u76f8\u5173\u6216\u53ef\u80fd\u7684\u6f5c\u5728\u5fc3\u529b\u8870\u7aed\uff0c\u5e76\u8003\u8651\u662f\u5426\u9700\u8981\u6cbb\u7597\u6216\u505c\u7528\u6ce2\u751f\u5766<\/li>\n\n\n\n<li>\u6cbb\u75971\u4e2a\u6708\uff0c3\u4e2a\u6708\u540e\u76d1\u6d4b\u8840\u7ea2\u86cb\u767d\u6c34\u5e73\uff0c\u4e4b\u540e\u6bcf3\u4e2a\u6708\u76d1\u6d4b\u4e00\u6b21<\/li>\n<\/ul>\n\n\n\n<p>\u836f\u7269\u76f8\u4e92\u4f5c\u7528\u6982\u8ff0<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u6ce2\u751f\u5766\u88abCYP2C9\u548cCYP3A\u4ee3\u8c22;&nbsp;\u6291\u5236\u8fd9\u4e9b\u9176\u53ef\u80fd\u4f1a\u589e\u52a0\u6ce2\u751f\u5766\u7684\u8840\u6d46\u6d53\u5ea6<\/li>\n\n\n\n<li>\u540c\u65f6\u7ed9\u4e88CYP2C9\u6291\u5236\u5242\uff08\u5982\u6c1f\u5eb7\u5511\uff0c\u80fa\u7898\u916e\uff09\uff0c\u5f3a\u6548CYP3A\u6291\u5236\u5242\uff08\u5982\u916e\u5eb7\u5511\uff0c\u4f0a\u66f2\u5eb7\u5511\uff09\u6216\u4e2d\u5ea6CYP3A\u6291\u5236\u5242\uff08\u5982\u5b89\u666e\u90a3\u97e6\uff0c\u7ea2\u9709\u7d20\uff0c\u6c1f\u5eb7\u5511\uff0c\u5730\u5c14\u786b\u5353\uff09\u53ef\u80fd\u4f1a\u5bfc\u81f4\u8840\u6d46\u6d53\u5ea6\u5927\u5e45\u589e\u52a0\u6ce2\u751f\u5766<\/li>\n\n\n\n<li>\u4e0d\u63a8\u8350\u5c06CYP2C9\u6291\u5236\u5242\u52a0\u5f3a\u6216\u4e2d\u7b49CYP3A\u6291\u5236\u5242\u4e0e\u6ce2\u751f\u5766\u7684\u8fd9\u79cd\u7ec4\u5408\u5171\u540c\u7ed9\u836f<\/li>\n\n\n\n<li>\u6ce2\u751f\u5766\u662fCYP3A\u548cCYP2C9\u7684\u8bf1\u5bfc\u7269;&nbsp;\u5f53\u5171\u540c\u65bd\u7528\u6ce2\u751f\u5766\u65f6\uff0c\u7531\u8fd9\u4e24\u79cd\u540c\u5de5\u9176\u4ee3\u8c22\u7684\u836f\u7269\u7684\u8840\u6d46\u6d53\u5ea6\u5c06\u964d\u4f4e<\/li>\n\n\n\n<li>\u964d\u4f4e\u6fc0\u7d20\u907f\u5b55\u836f\u7684\u529f\u6548<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h3 class=\"wp-block-heading\">\u9ed1\u5323\u5b50\u8b66\u544a<\/h3>\n\n\n\n<p>\u809d\u6bd2\u6027<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u89c2\u5bdf\u5230\u7ea611\uff05\u7684\u60a3\u8005ALT\u548cAST\u76843\u500dULN\u5347\u9ad8<\/li>\n\n\n\n<li>\u5728\u57fa\u7ebf\u65f6\u6d4b\u91cf\u8840\u6e05\u8f6c\u6c28\u9176\u6c34\u5e73\uff08\u5982\u679c\u6c28\u57fa\u8f6c\u79fb\u9176\u6c34\u5e73\u5347\u9ad8\u5219\u6d4b\u5b9a\u80c6\u7ea2\u7d20\uff09\uff0c\u7136\u540e\u6bcf\u6708\u6d4b\u91cf\u4e00\u6b21<\/li>\n\n\n\n<li>\u957f\u671f\u6cbb\u7597\u540e\u62a5\u544a\u7f55\u89c1\u7684\u4e0d\u660e\u539f\u56e0\u809d\u786c\u5316\u75c5\u4f8b\uff08&gt; 12\u4e2a\u6708\uff09<\/li>\n\n\n\n<li>\u907f\u514d\u5728\u57fa\u7ebf\u65f6\u6c28\u57fa\u8f6c\u79fb\u9176\u6c34\u5e73\u5347\u9ad8\uff08&gt; 3X 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